Objectives: Curcumin, a natural compound extracted from the rhizome of Curcuma longa L., was evaluated as a photosensitizer (PS) agent against Candida albicans. Methods: Prior to the photodynamic therapy (PDT) experiments, the absorption spectrum of Curcumin (Fluka) was analyzed to determine the optimal wavelength for illumination, which indicated the selection of a light emitting diode (LED) in the blue region of the spectrum (~455nm). Then, standard suspensions of Candida albicans (ATCC-90028) were photosensitized with nine Curcumin-concentrations (0.005, 0.01, 0.05, 0.1, 0.5, 1.0, 5.0, 10.0 and 20.0µM) and exposed to 37.5J/cm2 LED light fluence (n=5). Control suspensions were treated with PS concentrations only, or not exposed to LED light or PS. Serial dilutions were obtained and plated in duplicate on Sabouraud Dextrose Agar. After plates incubation (37°C for 48h), colonies were counted (CFU/ml) and the data were statistically analyzed with ANOVA and the Tukey's test (p<0.05). Results: Control samples showed substantial growth and had no significant changes in cell numbers throughout the course of the experiments. PDT mediated by Curcumin reduced the C. albicans viability in a concentration-dependent manner, ie, the higher the Curcumin-concentrations used, the lower the cfu-values observed. A significant reduction in cfu-values began to occur with the Curcumin-concentration of 0.1µM (p<0.05) and the highest concentration of Curcumin (20.0µM) resulted in complete killing of the yeast (no evidence of growth on plates). Conclusion: Curcumin proved to be a potential photosensitiser agent, as verified by the reduction of C. albicans viability after being photoactivated by blue LED light. The association of 20.0µM of Curcumin with LED light proved to be effective for completely killing the yeast. Curcumin without illumination had no antifungal activity against C. albicans. Grant: FAPESP 2008/03994-9.