Methods: The objects were healthy 99 patients who underwent oral surgery operation and had a steady sleep rhythm. The patients who had no premedication of atropine sulfate were randomly divided to placebo (Pla) group received saline intramuscularly, low dose (PML) group premedicated 0.04 mg/kg of midazolam and high dose (PMH) group received 0.06 mg/kg of midazolam 30 minutes before entering the operation room. Furthermore, the patients were divided to no premedication (non-PM) group and premedication (PM) group received 0.04 mg/kg of midazolam and 0.01 mg/kg of atropine sulfate intramuscularly 30 minutes before entering the operation room. The blood pressure, heart rate, peripheral blood flow, CgA and amylase in saliva measured on the day before the operation, 30 min before entering the operation room and entry into the operating room. Furthermore, we made the patients choose the picture most reflecting a mental state at that time by face anxiety scale (FAS) at each measuring time.
Results: In the PML and PMH group, the brood pressure on entry into the operating room significantly decreased compared to one day and 30 min prior to the operation and heart rate were unchanged throughout. The blood peripheral flow also significantly increased compared to Pla group and CgA in saliva significantly increased compared to it. CgA was almost corresponding to result of the amylase. In contrast, the FAS score showed an almost similar tendency in all groups, and the scores rose as the operation approached.
Conclusions: The CgA and amylase in saliva were almost corresponding to the results of brood pressure, heart rate, the peripheral blood flow and FAS. These results suggested that these indicator available to assess the preoperative psychogenic stress.