IADR Abstract Archives

Whitening Efficacy of a Novel Sensitivity Relief Dentifrice Containing Arginine

Background: A new dentifrice technology addressing tooth hypersensitivity has recently been commercialized. This technology employs 8.0% arginine, calcium carbonate and 1450 ppm monofluorophosphate (MFP). This daily use dentifrice has been shown clinically to reduce dentin hypersensitivity via occlusion of dentin tubules. Consumers now expect whitening options with their oral care products. This product was developed to address the whitening demands of consumers in need of efficacious sensitivity treatment.

Objective: The objective of this study was to evaluate the extrinsic stain removal efficacy of two sensitivity relief toothpastes containing 8.0% arginine, calcium carbonate, and 1450ppm MFP. One contained a high cleaning calcium carbonate system,(Test), the other contained standard calcium carbonate, (Control) over an eight week period of twice daily product use.

Methods: 100 healthy volunteers were recruited for an eight week, two-cell, double-blind, randomized clinical study. Using the standard method described by Lobene, teeth were scored for changes in stain area and intensity.

Results: The stain area for the Test product reduced from 2.42 (0.48) at baseline to 2.03 (0.57) to1.56 (0.61) for a 16% reduction at 4 weeks and a 35% reduction at 8 weeks, respectively. The stain area for the Control product reduced from 2.42 (0.47) at baseline to 2.3 (0.56) to 1.97 (0.63) for a 4.8% reduction at 4 weeks and an 18% reduction at 8 weeks. The stain intensity for the Test product reduced from 2.05 (0.53) at baseline to 1.58(0.53) to 1.24 (0.46) for a 23% reduction at 4 weeks and 39.5% reduction at 8 weeks. The stain intensity for the Control dentifrice reduced from 2.06(0.47) at baseline to 1.75(0.5) to 1.51(0.5) for a 15% reduction at 4 weeks and 27% reduction at 8 weeks.

Conclusion: The new breakthrough dentifrice technology for everyday relief of dentin hypersensitivity with stain prevention ingredients effectively delivers a whitening benefit.


Division: IADR/PER General Session
Meeting: 2010 IADR/PER General Session (Barcelona, Spain)
Location: Barcelona, Spain
Year: 2010
Final Presentation ID: 1417
Abstract Category|Abstract Category(s): Dental Materials 4: Clinical Trials
Authors
  • Zhang, Yun Po  ( Colgate Palmolive Technology Center, Piscataway, NJ, USA )
  • Yin, W  ( Colgate Palmolive Technology Center, Piscataway, NJ, USA )
  • Li, X  ( Colgate Palmolive Technology Center, Piscataway, NJ, USA )
  • He, S  ( Colgate Palmolive Technology Center, Piscataway, NJ, USA )
  • Ma, H  ( Colgate Palmolive Technology Center, Piscataway, NJ, USA )
  • Hu, D  ( Colgate Palmolive Technology Center, Piscataway, NJ, USA )
  • Monsul Barnes, Virginia  ( Colgate Palmolive Technology Center, Piscataway, NJ, USA )
  • Devizio, William  ( Colgate Palmolive Technology Center, Piscataway, NJ, USA )
  • SESSION INFORMATION
    Poster Session
    Clinical Research: Dentifrices and Bleaching Materials
    07/15/2010