Objectives: Candida-associated denture stomatitis is frequent among denture wearers. Recently, silver nanoparticles (AgNPs) has received attention as a possible antimicrobial agent. The aim of this study was to evaluate the effect of incorporation of AgNPs on the adhesion of Candida albicans to a denture base resin. Methods: Four groups consisted of a control (microwave-polymerized acrylic resin VIPI WAVE - VP) and 3 groups of modified VP containing AgNPs. The Ag nanoparticles were synthesized using a polymer [poly (vinyl alcohol) – PVA], or two cationic polyelectrolytes [poly (allylamine hydrochloride) – PAH; poly (dimethyldiallylammonium chloride) – PDAC] as stabilizers. The prepared AgNPs were incorporated with VP resin powder. Four resin disk-shaped samples (13.8 x 2mm) for each group were processed against glass plates to obtain smooth surfaces. The samples were placed in C. albicans (ATCC 90028) suspensions (107cells/ml) and incubated for 90 minutes at 37°C. The adherent cells were fixed in ethanol, stained with crystal violet and counted from 24 high-power light-microscopy fields of each sample. Data were analyzed by one-way ANOVA (p<.05). Results: No significant differences in the adhesion of C albicans were found among the specimens containing AgNPs (PVA – 191,67cells/mm2; PAH - 104,17cells/mm2; PDAC - 216,67cells/mm2). However, reduced adherence of yeasts was observed in these specimens in comparison to control specimens (900cells/mm2). Conclusions: The incorporation of AgNPs significantly reduced the adhesion of C. albicans to the acrylic resin surface, suggesting that AgNPs – combined denture base materials may be a potential approach to prevent denture stomatitis.