MicroCT Analysis of PepGen P-15 Putty After Sinus Augmentation

PepGen P-15 Putty is anorganic bovine hydroxyapatite matrix coupled with synthetic cell binding peptide (P15) mimicking the cell binding region of type I collagen suspended in a sodium hyaluronate carrier. “Objective:” To test the efficacy of PepGen P-15 Putty (DENTSPLY, CO) as a sole graft material after sinus augmentation in patients with significant loss of posterior maxillary ridge height. “Methods:” Sinus augmentation was performed in 12 patients (average bone height 4.95 ± 0.28mm) using PepGen P-15 Putty with immediate placement of two transient Xive dental implants 3.0mm in diameter aided by surgical stent. After 8 or 16 weeks implants were removed using a 4.25mm trephine bur followed by immediate placement of a wider diameter (5.5mm) Ankylos implants. The collected implants (20) were scanned by MicroCT to determine bone mineral density (BMD), percent bone volume (PBV), and percent bone contact (PBC). “Results:” There was a significant increase (P<0.05) in the BMD of bone around the implants at 8 weeks (0.51 ± 0.09 gm/cm3) and 16 weeks (0.58 ± 0.06 gm/cm3) compared to native (control) bone (0.04 ± 0.02 gm/cm3). There was no significant difference (P>0.05) in the PBV or PBC (PBV 73.72 ± 1.99 at 8 weeks, 72.99 ± 3.61 at 16 weeks and PBC 63.79 ± 1.78 at 8 weeks, 63.57 ± 4.17 at 16 weeks). The average increase in bone height at 16th week was 9.63 ± 1mm. MicroCT images showed the dense graft particles surrounded by trabecular bone. “Conclusion:” BMD increases as early as 8 weeks without further increase at 16 weeks. PepGen P-15 Putty was found to be a predictable osteoconductive graft for sinus augmentation supporting immediate placement of implants.

The clinical study was supported by the Egyptian government and materials from Dentsply Company.