Curcuma longa-ghee and hyaluronic acid effect on gingival healing

Currently, hyaluronic acid is applied to reduce side effects of periodontal surgery and enhance the wound repair. previous reports suggest that the local application of ghee and curcumin could promote the healing process. The purpose of this study was to compare the effect of Curcuma longa - ghee compound with hyaluronic acid on the gingival wound healing following surgery.

Methods:

In this single blind controlled randomized clinical trial, 5 male beagle dogs, 18 to 24 months old with intact teeth and no periodontal disease, were selected. Ghee was taken from the refined sheep butterfat. It was heated to 70„a C and at the same temperture mixed with the powdered rhizomes of curcuma longa. Gingivectomy was performed at the buccal gingiva of the teeth in six different regions of jaw. On the basis of a simple randomized allocation, untreated wounds in the two control areas were covered with periodontal pack and two these materials were applied topically in each two areas of four remaining test regions and then these areas were covered with periodontal pack. Histological changes were evaluated in days 4 and 7 after operation. The data was statistically analyzed by Kruskal-Wallis test.

Results:

We found significant differences of all inflammatory and repair parameters at both days 4 and 7 between the control group and the regions in which these materials were applied. When comparing this new material with hyaluronic acid alone, we observed meaningful differences between the epithelialization (P=0.002) at day 4; and also the inflammatory cells count (P=0.009), edema (P=0.004), necrosis, acute and chronic hemorrhage (P=0.001), fibroblast proliferation (P=0.023) and collagen density (P=0.014) at day7.

Conclusion:

From a clinical standpoint, this new formulation in comparison with hyaluronic acid indicated a positive potential therapeutic effects on acceleration of surgical wound healing particularly improvement of periodontal treatment consequences after surgery.