Material and Method: Sera were obtain from 25 adult periodontitis patients and 25 healthy control subjects selected from patients and their accompanied.
Serum lipid (Cholestrol, Triglycerid, HDL, LDL) assayed by a commercial laboratory. Periodontal treatment were done only for test group. 4-6 weeks after periodontal treatment, lipid were measured again in both group. The association between adult periodontitis and blood level of TG. Chol, HDL. LDL were examined by t-paired test and t-student test.
Results: The presence of periodontitis was significantly associated with elevated lipid level. In Test group the level of TG, Chol after periodontal treatment wers reduced significantly (P= 0.001, P= 0.006) but HDL, LDL were not change significantly.
In Control group, the level of TG, Chol were not change.
Conclusion: The result of this study indicate the presence of a significant relationship between periodontitis and hyperlipidemia but the exact mechanism has not been established. Systemic exposure to bacterial lipopoly saccharid can result in the release of inflammatory cytokins such as Il-1á and TNF-â that alter fat metabolism and promote hyperlipidemia.
Key words: Triglyceride, Cholestrol, Cytokine, Hyperlipidemia, periodontiist, Periodont pathogen .