IADR Abstract Archives

Association Between Interleukin-6 Haplotypes and Aggressive Periodontitis

Single nucleotide polymorphisms with supposed functional effect have been identified in the gene coding for the pro-inflammatory cytokine Interleukin-6 (IL-6). A deregulation of IL-6 production, determined by the combined effect of these polymorphisms, may predispose to periodontal destruction.

Objectives: This study aimed at investigating the possible role of IL-6 genetic polymorphisms and haplotypes in the predisposition to Aggressive Periodontitis (AgP).

Methods: A case- control association study on 224 AgP patients and 231 healthy controls was performed to detect differences in genotype distributions of 5 single nucleotide polymorphisms (SNPs) located in the IL-6 gene promoter (-174, -572, -1363, -1480 and -6106). The possible effect of each SNP was investigated (by SPSS software), together with the effect of their combinations (haplotypes) (by WHAP package).

Results: All studied SNPs exhibited linkage disequilibrium between them. The most remarkable associations with the disease phenotype were detected between the -1480 polymorphism and LAgP, in subjects of mixed ethnicities (p= 0.003 at logistic regression adjusting for gender, ethnicity and smoking) and Caucasians (p=0.010, adjusting for gender and smoking). Haplotypes determined by the -1363 and -1480 SNPs were associated with LAgP (p=0.001 adjusting for gender and smoking) in Caucasians.

Conclusions: this study supports the importance of Interleukin-6 polymorphisms (at position -1363 and -1480) in Aggressive Periodontitis and highlights the importance of IL-6 haplotypes in determining disease susceptibility.


IADR/AADR/CADR General Session
2007 IADR/AADR/CADR General Session (New Orleans, Louisiana)
New Orleans, Louisiana
2007
87
Periodontal Research - Pathogenesis
  • Nibali, Luigi  ( UCL Eastman Dental Institute, London, N/A, United Kingdom )
  • Donos, Nikolaos  ( UCL Eastman Dental Institute, London, N/A, England, Uk )
  • Parkar, Mohamed  ( Eastman Dental Institute for Oral Health Care Sciences, London, N/A, United Kingdom )
  • D'aiuto, Francesco  ( UCL Eastman Dental Institute and Hospital, London, N/A, United Kingdom )
  • Tonetti, Maurizio  ( University of Connecticut Health Science Center, Farmington, CT, USA )
  • Griffiths, Gareth  ( University of Sheffield, Sheffield, N/A, United Kingdom )
  • Brett, Peter  ( Eastman Dental Institute, London, N/A, England, Uk )
    • Oral Session
    Periodontal Pathology - Gene expression
    03/21/2007