GUI removable partial denture design software integrated with best-practice rules of design educates dental students approaching RPD design for the first time and reminds practicing dentists of critical considerations. Intended for use in institutional and private practice settings, this stand-alone application aids busy practitioners in RPD treatment planning by integrating guidelines and indications/contraindications in each design element. The final output of the application is a printable lab prescription of the user’s design to be sent with models for fabrication of the RPD. Intended to be cross-platform, the software was designed using Macromedia Flash MX on a PC running Windows XP. Images used were edited in Adobe PhotoShop 7.0 and drawn as vector graphics in Flash. The interface was designed for users with no specific technological expertise. Navigation in the interface is point-and-click. The software will be evaluated for ease-of-use and educational value in two study groups: students with no prior RPD design training and practitioners who have completed at least one course in RPD design. Participants will be presented the same partially edentulous model and a description of clinical findings. Participants will be asked to design a RPD for the fictitious patient using the software. Designs from each group will be evaluated for clinical acceptability, allowing a comparison of the groups’ designs with and without outside training. Participants will complete a survey, including a self-evaluation of level of comfort with technology and experience using the software. A beta version of the software will be developed considering user feedback from study results and surveys. The application intends to enhance RPD design educational experiences for students as well as streamline design processes for practicing dentists. Using a digital interface that includes best-practice rules, many designs for the same case can be evaluated and a reasonable comparison can be assessed more easily than hand-drawn designs using textbook references.