IADR Abstract Archives

Periodontal Disease, Inflammatory Mediators, and Prematurity

Objectives: To evaluate the risk factors for pre-term delivery and low birth weight with special emphasis on periodontal pathogens in plaque and cervico-vaginal samples and serum inflammatory mediators during pregnancy. Methods: Study design is a nested case-control study conducted at Yale University and a prospective follow-up study that is being conducted at the Bellevue Hospital, New York. Primary Outcomes are gestational age based on ultra sound examination and LMP and birth weight. Primary independent Variables are periodontal pathogens in sub-gingival plaque samples and cervico-vaginal samples (multiplex PCR assay and DNA probes in a checkerboard assay), and IL-6, IL-8, and TNFa. Results: In the nested case-control study, there were 69 preterm deliveries and 150 full-term deliveries, 35 low birth weight deliveries and 184 normal birth weight deliveries, and 28 preterm low birth weight deliveries and 191 full-term normal birth weight deliveries. In the Bellevue follow-up study, as of September 30, 2005, 164 subjects have been recruited. Only 47 of these have delivered at last count. As the study is still in progress, here we report some preliminary data from a sub-sample. Subjects were predominantly Hispanic and were around 30 years of age. There were no statistically significant differences between groups in serum IL-6, IL-8, and TNFa. Based on the analysis of cervical, vaginal, and plaque samples from 25 subjects from the Bellevue follow-up study, we were able to demonstrate P. gingivalis in plaque (20%), cervical (8.7%), and vaginal samples (8%). Corresponding proportions for T. forsythia and A. actinomycetemcomitans are: 20%, 0%, 4% and 16%, 17.4%, 0%. Conclusion: Preliminary data suggest no association between elevated serum IL-6, IL-8 and TNFa levels and preterm delivery. Demonstration of periodontal pathogens in cervical and vaginal samples in addition to plaque samples strengthens the biological plausibility of the hypothesized association. NIH/NIDCR Grant RO1 DE015594-01.
AADR/CADR Annual Meeting
2006 AADR/CADR Annual Meeting (Orlando, Florida)
Orlando, Florida
2006
57
Periodontal Research - Diagnosis / Epidemiology
  • Dasanayake, Ananda P.  ( New York University, New York, NY, USA )
  • Kuczynski, Edward  ( Yale University, New Haven, CT, USA )
  • Lee, Men-jean  ( Yale University, New Haeven, CT, USA )
  • Lockwood, Charles  ( Yale University, New Haeven, CT, USA )
  • Kanasi, Eleni  ( The Forsyth Institute, Boston, MA, USA )
  • Walla, Matt  ( New York University, New York, NY, USA )
  • Tanner, Anne  ( The Forsyth Institute, Boston, MA, USA )
  • Craig, Ron  ( New York University, New York, NY, USA )
  • Saito, Hanae  ( New York University, New York, NY, USA )
  • Tam, Mae  ( New York University, New York, NY, USA )
  • Chen, Weiti  ( New York University, New York, NY, USA )
  • Wein, Rosemary  ( New York University, New York, NY, USA )
  • Piyathilake, Hasitha  ( New York University, New York, NY, USA )
    • Oral Session
    Periodontal Diagnosis
    03/08/2006