Oral Health Program Using LSTR 3Mix-MP NIET Therapy

Objectives: This study aimed to evaluate the second year 3Mix-MP one-time endodontic treatment using a combination of antibacterial drugs, metronidazole, minocycline and ciprofloxacin (3Mix), and macrogol and propylene glycol (MP) under the concept of ‘Lesion Sterilization and Tissue Repair (LSTR) therapy'. The treatment was carried out on the first molars of school children as a 4-year program at two sites: Shibchar, Bangladesh and Alfonso, Philippines. Methods: Under informed consent, 416 children of Shibchar and 103 of Alfonso were examined, and 54 and 16 first molars were treated, respectively. After free enamel was removed, 3Mix-MP was placed at each orifice of root canal without root canal preparation and filling (non-instrumentation endodontic treatment: NIET), sealed with glass-ionomer cement (GI) and further reinforced by a direct bounded resin-inlay (RI), composite-resin (CR) or second GI. Results: Caries prevalence in Shibchar was 89% (dmf: 1.56) and 17% (DMF: 0.33) for 5-13 year olds in the primary and permanent dentitions, and 73% (dmf: 3.07) and 26% (DMF: 0.55) for the 7-8 year olds in Alfonso, respectively. In Shibchar, out of 54 first molars, all of the 25 cases of LSTR 3Mix-MP with RI and 7 cases using CR were evaluated to be successful because of no clinical disorders on bite since treated. Out of 16 cases of LSTR 3Mix-MP with GI, 13 were successful, but the restorations were lost in 3 cases around 3 months after the treatment although there were no clinical disorders and the canals were closed by calcification. The other 6 cases were given sealant treatment. In Alfonso, all the 16 cases were successful using LSTR 3Mix-MP with CR, although in one case the CR margin was reinforced. Conclusion: One-time endodontic treatment using LSTR3Mix-MP NIET results in excellent clinical outcomes in rural oral health program.