Tailor-made tricalcium phosphate bone implant directly fabricated by ink-jet printer
Objective: Rapid prototyping (RP) is a molding technique that builds a three-dimensional (3D) model from a Computer Aided Design (CAD) data. We created new tailor-made bone implants (TI) from alpha-tricalcium phosphate powder, using an RP inkjet printer based on computed tomography (CT) data, and evaluated their safety and efficacy. Methods: CT data of the skulls of seven beagle dogs were obtained and converted into CAD data, and bone defects were virtually made in the skull bilaterally. TI were designed to fit to the defects and created using the 3D ink-jet printer; 6 horizontal circular cylinders running through the implants were newly designed for possible facilitation of vascular invasion and bone regeneration. As a control, hydroxyapatite implants (HI) were cut out manually from porous hydroxyapatite blocks. Then, craniectomy was performed to create real skull defects, and TI and HI were implanted. After implantation, CT was performed regularly, and the animals were euthanized at 24 weeks. Results: No major side effects were observed. CT analysis showed narrowing of the circular cylinders; bony bridging between the implants and the temporal bone was observed only in TI. Histological analysis revealed substantial new bone formation inside the circular cylinders in TI, while mainly connective tissues invaded porous structures in HI. Bone marrow was observed only in TI. Osteoclasts were seen to resorb regenerated bone from inside the circular cylinders and to invade and probably resorb TI. Conclusion: These data suggest that TI is a safe and effective bone substitute, possessing osteoconductivity comparable with that of HI.
Division: IADR General Session
Meeting:2006 IADR General Session (Brisbane, Australia) Location: Brisbane, Australia
Year: 2006 Final Presentation ID:211 Abstract Category|Abstract Category(s):Implantology Research
Authors
Igawa, Kazuyo
( University of Tokyo, Tokyo, AL, Japan
)
Chung, Ung-il
( University of Tokyo Hospital, Tokyo, N/A, Japan
)
Mochizuki, Manabu
( Tokyo University of agriculture and technology, Tokyo, N/A, Japan
)
Suzuki, Suzuki
( New X-national Technology K.K, Tokyo, N/A, Japan
)
Ohba, Shinsuke
( University of Tokyo, Tokyo, AL, Japan
)
Kugimiya, Fumitaka
( University of Tokyo Hospital, Tokyo, N/A, Japan
)
Ogasawara, Toru
( University of Tokyo, Tokyo, AL, Japan
)
Tomizuka, Ken
( University of Tokyo, Tokyo, AL, Japan
)
Sasaki, Nobuo
( University of Tokyo, Tokyo, N/A, Japan
)
Takato, Tsuyoshi
( University of Tokyo, Tokyo, AL, Japan
)