GBR Combinating With Platelet-rich Plasma on Alveolar Defect Repairing

Objective: The loss of teeth always results in bone resorption and loss of interdental papillae, and the quality and quantity of bone are the basic factors in treatment planning and determine the type of implant to be used. The resorption and bone defects limit the application of dental implant. Guided Bone Regeneration (GBR) using membrane is a good technique to restore local bone defects. The new method sufficiently utilizes the potential ability in organis by means of placing barrier membrane. Platelet-rich plasma(PRP) is comprised of various growth factor. The study evaluates the bone formation of bioresorbable collagen membrane when used alone or in combination with PRP in dog alveolar bone defects. Methods: Three male mongrel dogs were used. The first and second premolars were extracted from the bilateral maxillary and mandibular bone and four alveolar intrabone defects(8mm in height, 5mm in width,15mm in length) were created. The surgically-created defects were randomly assigned to one of the treatments: (A) control (nothing was used), (B) GBR(only Bio-Gide), (C) GBR+ PRP (Bio-Gide+PRP). The dogs were sacrificed at 4, 8, and 12 weeks after the surgery. The macroscopicAradiographic and histological processing were performed. Results: The amount of newly formed bone was significantly greater in the groups using the membrane than in the control group within 8 weeks. However, there were no apparent differences between the use of the collagen barrier membrane alone or in combination with PRP in enhancing new bone formation. Conclusion:The results of this study indicate that GBR treatment with collagen membranes may significantly enhance bone regeneration within 8 weeks. The influence of GBR technique in combination with PRP in accelerating the repair of alveolar bone defects is not clear.