Treatment of Experimental Peri-Implantitis Using Platelet-Enriched Fibrin Glue

Objective:The purpose of this study was to evaluate the effects of autogenous bone grafts and platelet-enriched fibrin glue in the treatment of peri-implantitis. Methods:36 screw-type, commercially-pure, titanium implants with rough acid-etched surfaces were inserted into six mongrel dogs, three months after extraction of mandibular premolars. After three months of healing, peri-implantitis was induced by placing gauzes and wires around the implants. Once peri-implantitis was created, surgical treatments involving a combination of autogenous bone grafts and platelet-enriched fibrin glue, autogenous bone grafts alone, or a conventional flap procedure only (control) were carried out. Six months later, biopsies of the implant sites were taken and prepared for ground sectioning and analysis. Results:The amount of re-osseointegration was significantly higher in peri-implantitis defects treated with combined autogenous bone grafts and platelet-enriched fibrin glue as compared with the other two treatment procedures. A mean bone-to-implant contact of 50.1% was obtained in the peri-implantitis lesions treated with combined autogenous bone grafts and platelet-enriched fibrin glue. The corresponding values for the autogenous bone grafts and control groups were 19.3% and 6.5%, respectively. Conclusion:The present study demonstrates that surgical treatment involving the combined use of autogenous bone grafts and platelet-enriched fibrin glue might effectively promote re-osseointegration in lesions resulting from peri-implantitis.