Regenerative periodontal surgery with PRP, beta-tricalciumphosphate and GTR

Objective: To compare the healing of intrabony defects with a combination of Platelet Rich Plasma (PRP) + β-Tricalcium Phosphate (β-TCP) + a non bioresorbable membrane (GTR) to β-TCP + GTR. Methods: 24 patients each of whom exhibited 1 deep intrabony defect were randomly treated with either PRP + β-TCP + GTR or with β-TCP + GTR. Probing pocket depth (PPD), gingival recession (GR) and clinical attachment level (CAL) were recorded at baseline and at 6 months. Results: No statistical significant differences in any of the investigated parameters between the two groups were observed at baseline. In the PRP + β-TCP + GTR group mean PPD decreased from 8.6 ± 1.6 mm to 2.1 ± 1.2 mm (p<0.0001) and mean CAL changed from 9.3 ± 1.5 mm to 4.2 ± 1.3 mm (p<0.0001). In the β-TCP + GTR group mean PPD decreased from 8.8 ± 2.2 mm to 2.7 ± 1.6 mm (p<0.0001) and mean CAL changed from 9.7 ± 2.2 mm to 4.3 ± 2.1 mm (p<0.0001). At 6 months after therapy there were no statistically significant differences in any of the investigated parameters between the 2 groups. Conclusion: Both treatments resulted in significant PPD reductions and CAL gains. Further studies are needed in order to evaluate a possible advantage of PRP in the regenerative treatment of intrabony defects.