Regenerative treatment with Bio-Oss Collagen and Bio-Gide PERIO

Objective: To compare clinically the treatment of deep intrabony defects with a combination of a composite bovine derived xenograft (BDX Coll) and a bioresorbable collagen membrane (GTR) to access flap surgery. Methods: Thirty-two patients each of whom displayed one intrabony defect were treated either with BDX Coll + GTR (test) or with access flap surgery (control). The results were evaluated at one year following therapy. Results: No differences in any of the investigated parameters were observed at baseline between the two groups. At 1 year after therapy the test group showed a reduction in mean probing depth (PD) from 8.3 ± 1.5 mm to 2.9 ± 1.3 mm (p<0.001) and a change in mean clinical attachment level (CAL) from 9.4 ± 1.3 mm to 5.3 ± 1.5 mm (p<0.0001). In the control group mean PD was reduced from 8.0 ± 1.2 mm to 4.4 ± 1.7 mm (p<0.001) and mean CAL changed from 9.6 ± 1.3 mm to 7.9 ± 1.6 mm (p<0.01). The test treatment resulted in statistically higher PD reductions (p£0.05) and CAL gains (p< 0.001) than the control one. In the test group all sites (100%) gained at least 3 mm of CAL. In this group a CAL gain of 3 or 4 mm was measured at 10 sites (62%), whereas at six sites (38%) the CAL gain was 5 or 6 mm. In the control group no CAL gain occurred at 3 sites (18%), whereas at 10 sites (57%) the CAL gain was 1 or 2 mm. A CAL gain of 3 mm or more was measured in 4 defects (25%). Conclusions: The combination of BDX Coll + GTR resulted in significantly higher CAL gains than treatment with access flap surgery and thus, appears to be a suitable alternative for treating intrabony periodontal defects.