The progress of periodontitis and its association with IL-1 polymorphism

Objectives: To study the natural progress of chronic periodontitis and its association with IL-1genetic polymorphisms. Methods: 166 subjects with chronic periodontitis were examined at baseline and in 1 year on probing depth, attachment level and bleeding on probing on 6 sites of each tooth .111 subjects were genotyped for IL-1-889 and IL-1+5934 genetic polymorphisms with PCR-RFLP. DNA samples were obtained with buccal swabbing technique. Results: The mean PD, AL increases were 1.12 mm, 1.628 mm respectively within 1 year. Among 166 subjects, 94 patients with 249 sites had >=2mm attachment loss over one year period. There was no significant difference for the distribution and frequency of IL-1-889 genotypes and alleles between the rapidly progressive group (with AL>=2mm at least one site) and the non-rapidly progressive group. The distribution of IL-1+5934 genotype 1/2 and the frequency of the allele 2 were significantly higher in the rapidly progressive group than in the non-rapidly progressive group (P<0.05), although they were both quite low. There was no significant difference of PD and AL changes in one-year period between different genotype carriers of IL-1A-889 and IL-1B+3954. Conclusion: The progress of chronic periodontitis varies individually, and further studies should be taken to elucidate the relationship between the progress of chronic periodontitis and the genetic polymorphisms of IL-1.