Comparison of Platelet-Rich Plasma and Emdogain-gel on The Periodontal Regeneration

Materials and Methods: Palatal dehiscence defects were surgically created on the bilateral maxillary first molars in fifty rats. PRP derived from allogenic blood and Emdogain-gel were used. Atelocollagen was used as a carrier. Both sides of periodontal defects were filled with atelocollagen containing PRP (PRP group) or with atelocollagen containing Emdogain-gel (EMD group). Moreover, both sides of periodontal defects were filled with only atelocollagen (AC group). Five rats in each group were euthanized 2,4 and 8 weeks after surgery. Demineralized paraffin sections were histologically observed, and histomorphometric measurements were performed.

Results: The rate of bone regeneration was the largest in the PRP group, and there were statistically significant differences between the PRP group and the EMD group, two and eight weeks after surgery. The rate of new cementum formation was largest in the EMD group, and there were statistically significant differences between the EMD group and the PRP group, four and eight weeks after surgery.

Conclusions: The results suggested that implanting PRP in periodontal defects significantly promoted bone regeneration, but the effect of PRP on the formation of new cementum was inferior to that of Emdogain-gel.