Objectives: This study was conducted to investigate the eruption pattern of cleft side canine concerning its relation to the cleft site in secondary bone grafted and non-grafted patients. Materials and Methods: Fifty-nine alveolar clefts in 53 cleft lip and palate patients (21 bone grafted, 32 non-grafted) were examined using panoramic radiographs and posteroanterior cephalograms, taken at two stages, before and after canine eruption. All subjects were divided into three groups, bone grafted (bone grafting was performed before canine eruption), non-grafted and control (non-cleft side). Canine at pre-eruption stage was divided into two groups on the basis of orthopantomographic analysis, I) close to, and II) distant from the cleft site. Canine angle, which was measured between its major axis and a horizontal reference line, and its change between two stages were evaluated. Results: 1. Orthopantomographic analysis showed: 1) There was not found significant difference between initial canine angles of grafted and non-grafted samples, however control group showed higher angle compared to grafted (p<0.05) and non-grafted (p<0.01) samples. 2) While canine in grafted group erupted without significant angle change, canine angle increased significantly in non-grafted (p<0.0001) and control (p<0.0001) groups. 3) In Group I, greater canine angle change was found in non-grafted (p<0.05) and control (p<0.01), than in grafted samples, however in Group II, significant difference was not found between grafted, non-grafted and control samples. 2. The same results were obtained from cephalometric measurements and high correlation was found between two measurements (r=0.88). Conclusion: These results suggest that canine located near to the cleft erupts with the same angulations as it had before grafting in grafted samples, however in non-grafted samples it erupts with more vertical direction, guided by cortical bone, same as canine in non-cleft side of control group.