In Situ Remineralisation of Demineralized Enamel Using CHX/NaF-Mouthrinse

Objective: Purpose of this in situ study was to evaluate the remineralisation of demineralized enamel specimens using a CHX/NaF mouthrinse in comparison to a CHX- and a placebo-mouthrinse. This 3-way cross-over designed study conformed to good clinical practice. Methods: 24 volunteers received intraoral appliances with mounted demineralized enamel specimens. They rinsed their mouths twice a day (10ml/1min) with the respective mouthrinse. After 14 days, in situ mineral gain and fluoride uptake were determined. Statistical analysis of the results of ANOVA inter-group comparisons were made by paired t-tests. Results: Mineral gain was significantly higher after using CHX/F mouthrinse [358.4 Vol.%•µm] compared to CHX [95.6 Vol.%•µm] and placebo treatment [80.8 Vol.%•µm]. Besides CHX/F treatment [2751.1 µg/cm3] resulted in a significantly higher amount of fluoride uptake compared to CHX- [3.8 µg/cm3] and placebo- [136.6 µg/cm3] mouthrinses. Conclusions: The in situ study approves, that using a CHX/F mouthrinse supports remineralisation of initial carious lesions.