Increased Toluidine Blue Uptake in Oral Leukoplakia from Previous Cancer Sites Predicts Increased Risk of Tumor Development
Objective: The determination of when and where to biopsy oral premalignant lesions (OPLs) at the fragile prior cancer site is a continuing challenge facing clinicians since treatment of cancer induces reactive changes that often resemble OPLs (leukoplakia/erythroplakia). We have recently shown that toluidine blue (TB) staining helps to identify OPLs with high-risk molecular clones in patients without a history of oral cancer. The aim of this study was to investigate whether TB could identify high-risk OPLs in patients with a history of oral cancer.
Method: In an ongoing prospective study, the following information were collected from 59 patients with a history of oral cancer: demographics (age, gender and habit); features of primary oral cancer (TNM staging, histological grading and treatment), and features of OPLs (presence/absence of OPLs; clinical appearance, size, TB staining, pathology and outcome).
Results: Of the 59 patients, 27 developed cancer at the previous cancer sites (called recurrent group) while 32 did not (called non-recurrent group). There were no differences between the recurrent and non-recurrent groups with respect to the demographic characteristics and features of primary oral cancer. OPLs that went on to become recurrent cancer tended to be larger (55% ³ 1 cm versus 27% in nonrecurrent group) and nonhomogeneous (62% versus 27% in nonrecurrent group) although the differences were not significant. There were no differences in the pathology and treatment of OPLs between the two groups. However, 62% of OPLs in the recurrent group stained TB positive as compared to 33% of OPLs in the non-recurrent group (P = 0.05).
Conclusion: TB staining could facilitate the identification of high-risk OPLs in patients with previous history of oral cancer
(Supported by grant R01DE13124, NIDCR & by Head and Neck Cancer Foundation scholarships).
Division: AADR/CADR Annual Meeting
Meeting:2003 AADR/CADR Annual Meeting (San Antonio, Texas) Location: San Antonio, Texas
Year: 2003 Final Presentation ID:63 Abstract Category|Abstract Category(s):Oral Medicine & Pathology
Authors
Zhang, Lewei
( The University of British Columbia, Vancouver, BC, Canada
)
Le, Nhu
( British Columbia Cancer Agency, Vancouver, N/A, Canada
)
Lam, Wan L
( BC Cancer Agency, Vancouver, BC, Canada
)
Berean, Ken
( Vancouver Hospital & Health Sciences Centre, Vancouver, N/A, Canada
)
Hay, John
( British Columbia Cancer Agency, Vancouver, BC, Canada
)
Rosin, M.p.
( British Columbia Cancer Agency, Vancouver, BC, Canada
)
Williams, Michele
( British Columbia Cancer Agency, Vancouver, N/A, Canada
)
Laronde, Denise
( The University of British Columbia, Vancouver, BC, Canada
)
Epstein, Joel B.
( British Columbia Cancer Agency, Vancouver, N/A, Canada
)
Durham, Scott
( Vancouver Hospital & Health Sciences Centre, Vancouver, N/A, Canada
)
Hovan, Alan
( British Columbia Cancer Agency, Vancouver, N/A, Canada
)
Nakamura, Hisae
( Simon Fraser University, Burmaby, BC, Canada
)
Poh, Catherine F.
( The University of British Columbia, Vancouver, BC, Canada
)
Hislop, Greg
( British Columbia Cancer Agency, Vancouver, N/A, Canada
)
SESSION INFORMATION
Oral
Oral Cancer and Precancer - Diagnosis and Biomarkers
03/12/2003