Ozone continues to be investigated as a pharmaceutical treatment for pit and fissure carious lesions (PFCLs) in a longitudinal controlled clinical trial.
Aim: To continue to monitor lesions' remineralisation, arrest or progression after Ozone treatment.
Methods: 240 permanent teeth with non-cavitated occlusal PFCLs in 78 patients were enrolled. Teeth were cleaned using air-abrasive system (Prophyflex 2®, KaVo, Germany) and the following were recorded: clinical severity (Ekstrand, 1998), DIAGNOdent® (KaVo, Germany) and ECM (LODE BV, Netherlands) standard scale baseline (site-specific) readings. After randomisation, 120 lesions were treated with Ozone for 10 seconds (HealOzone unit, CurOzone USA) and the other 120 were reserved as controls. The procedure was repeated at 1, 3 and 6 months. The changes in the ECM values were tested by one sample t-test of log
e m/base and 2-way analysis for block and treatment effects. The effect of the following co-variables was tested: tooth location, lesion location (mesial, central or distal) and type (pit or fissure), base line DIAGNOdent, and clinical severity classification.
Results: The ECM values in the treatment group were significantly higher than the base line values (p<0.01), while it was not for the control group (p>0.05). The mean ECM change for the treatment group was 1.5 times the baseline value and this was significantly higher (p<0.05) than that for the control group (0.9 times the baseline). On the other hand, there were no significant patient treatment interactions and none of the tested factors had a significant effect.
Conclusion: Ozone treatment of PFCLs showed significant remineralisation at 6 months. All Ozone treated teeth responded similarly regardless of the tooth’s or lesion’s location, type and severity. (Supported by CurOzone, USA).