Handwashing is the cornerstone of infection control yet compliance with handwashing guidelines has been found to be unacceptably low. Recent studies have shown the use of waterless handwashing products is effective and more time efficient than soap and water and has increased handwashing compliance. Objective: The objective of this study is to compare handwashing using traditional antimicrobial soap and water (S/W) with two antimicrobial waterless handwashing products for personal preference and compliance. Methods: 35 dental students were randomly chosen to participate in the study. All subjects were anonymously observed prior to the introduction of the waterless products for handwashing compliance using S/W for 1 week. All subjects were then instructed on the use of a gel (G) and a foam (F) for handwashing. Both waterless products were used for a period of 1 week and students were again anonymously observed. A questionnaire was distributed at the conclusion of the study to determine product preference. Survey results were analyzed using Chi-square. Results: During handwashing with S/W, the average contact time with the soap was 7.96 sec. The average contact time with G and F were 17.2 sec and 20.8 sec, respectively. Questionnaire results indicated that F was significantly preferred over G and S/W (63%, 29% and 9% respectively). F was also significantly preferred when evaluating fragrance (57%), kindness to the skin (74%) and convenience (71%). G was significantly preferred when evaluated for fastest drying time (54%). Conclusion: Results from this study indicate that foam was significantly preferred over gel and traditional soap and water for handwashing procedures. Since handwashing guidelines, regardless of which product used, recommend a minimum of 15 seconds to minimize the number of transient microorganisms on the hands, compliance was found only with the foam and the gel.