IADR Abstract Archives

A Bioresorbable Calcium Carbonate Coral Implant Enhances Alveolar Bone Regeneration in Conjunction with Guided Tissue Regeneration

Objectives: Compression of the barrier device into a periodontal defect or onto the root surface will compromise outcomes following guided tissue regeneration (GTR). Bone biomaterials have been suggested to support regeneration of alveolar bone and periodontal attachment. Such biomaterials may potentially also offer advantages in supporting stability and spatial provision of GTR devices. The objective of this study was to evaluate spatial provision, alveolar bone and cementum regeneration following use of a resorbable, calcium carbonate biomaterial (Biocoral® 1000) in conjunction with GTR.

Methods: Routine, supraalveolar, periodontal defects were created in five Beagle dogs. Alternate jaw quadrants in consecutive animals received GTR (GORE-TEX® Regenerative Material) and the coral biomaterial (cGTR) or GTR alone. The animals were euthanized at 4 weeks postsurgery and tissue blocks processed for histometric analysis.

Results: All defect sites exhibited radiopacity consistent with bone deposition. cGTR defects demonstrated a granular radiopacity, bone formation being observed within the granular material continuous with resident bone. Space provision was enhanced in cGTR compared to GTR sites (6.2 ± 1.5 vs. 2.1 ± 1.0 mm2; p=0.0144). Bone regeneration (height and area) averaged 1.5 ± 0.8 vs. 1.1 ± 0.1 mm, and 3.1 ± 1.6 vs. 1.3 ± 0.6 mm2 for cGTR and GTR sites, respectively (p > 0.05). The coral implant particles were surrounded by newly formed bone or immersed in connective tissue. Osteoclastic and osteoblastic cells were apparent in close contact with coral particles embedded in connective tissue. Particles embedded in bone surrounded by osteoclastic and osteoblastic cells appeared to be resorbing and replaced by bone. There was limited appreciable cementum regeneration for any site.

Conclusions: Use of the coral implant significantly enhanced GTR space provision while alveolar bone formation appeared to be enhanced by its use. Increased healing intervals are needed to fully appreciate the biologic value of this implant as an adjunct to GTR.


IADR/AADR/CADR General Session
2002 IADR/AADR/CADR General Session (San Diego, California)
San Diego, California
2002
3927
Periodontal Research - Therapy
  • Wikesjö, Ulf Me  ( Temple University School of Dentistry, Philadelphia, PA, USA )
  • Lim, Won Hee  ( Temple University School of Dentistry, Philadelphia, PA, USA )
  • Razi, Saghi S  ( Private Practice, Beverly Hills, CA, USA )
  • Sigurdsson, Thorarinn J  ( University of Akureyri, Akureyri, N/A, Iceland )
  • Lee, Michael B  ( Loma Linda University, Loma Linda, CA, USA )
  • Tatakis, Dimitris N  ( Ohio State University, Columbus, OH, USA )
  • Hardwick, W Ross  ( W.L. Gore & Associates, Inc, Flagstaff, CA, USA )
    • Oral Session
    GTR and New Bone Grafting Materials
    03/09/2002