Evaluation of Miconazole and Micostatin gel for treating denture stomatitis

Denture stomatitis can be managed with the topic application of antifungal gels. Objective: To compare Miconazole and Mycotatin gel for the treatment of denture stomatitis. Methods: 30 patients attending the Prosthetic Clinic, U Witwatersrand were investigated, 14 were treated with topical Miconazole gel and 16 with Mycostatin. They were examined initially and after 2, 4, 7, 11, 14, 28 and 56 days treatment. Scrapings taken from the palate and denture at each visit were plated on Sauborauds Agar, incubated at 37oC for 48 hours and identified using the API 20C. Results: After 8 weeks treatment a third of the patients on Miconazole and Mycostatin were healed. Within 7 days there was a moderate improvement in 36% of patients on Miconazole and 75% of patients on Mycostatin. After 8 weeks this deceased to 18% on Miconazole and 57% on Mycostatin. None of these differences were significant. All patients carried oral yeasts. C. albicans was isolated from all the patients treated with Mycostatin and 11 of the 14 patients on Miconazole. C. krusei, C tropicalis, Saccaromyces cereviseae and Torulopsis glabrata were found less frequently. After 7 days treatment with Miconazole, yeasts were cultured from 7% of the sites sampled. This increased to 29% after 8 weeks treatment. The percentage of sites with yeasts in patients on Mycostatin was 25% after 7 days and 31% after 8 weeks. Conclusions: After 8 weeks treatment with Miconazole and Mycostatin gel there was no difference in the percentage of patients who were healed and sites that yielded yeasts. Mycostatin was more sucessful than Miconazole in promoting a moderate improvement in the clinical status of patients with denture stomatitis