Effect of a moose type topical anesthetic in dentistry

Objectives: We made a moose of topical anesthetic, which was made of 8% lidocaine and each application contains 15mg of lidocaine. In this study, the topical anesthetic effect of the new agent was examined. Methods:Twelve healthy volunteers participated in four kinds of experiment. Group P: the placebo moose was sprayed on the mucobuccal region of the root apex of the upper incisor, and the infiltration anesthesia was performed at 5 minutes after application. In the following three groups, the lidocaine moose was sprayed on the same region of Group P. Group 1M: at 1 minute after application, the infiltration anesthesia was performed. Group 3M: at 3 minutes after application, the infiltration anesthesia was performed. Group 5M: at 5 minutes after application, the infiltration anesthesia was performed. The infiltration anesthetic used was 2% lidocaine containing 1/73,000 epinephrine (0.3ml/30sec). The intensity of pain was recorded twice when the needle was inserted and during the injection. The pain score was assessed into the five grades from 1 (no pain) to 5 (worst pain). Results:The pain score when the needle was inserted was 2 (median) in Group 1M, 1 in Groups 3M and 5M, and 3 in Group P. The score in Groups 1M, 3M, and 5M were significantly lower than those in Group P. The pain score during the injection was 2 in Groups 1M and 3M, 1 in Group 5M, and 3 in Group P. The score in Group 5M was significantly lower than that in Group 1M, and the scores in Groups 3M and 5M were significantly lower that in Group P. Conclusion:The lidocaine moose is effective to relieve the pain when the needle is inserted and during the injection, and the effect is stronger when it is applied 3 minutes or more prior.