Effect of Calcium Hydroxide Paste on Bone Formation

Objectives:The purpose of this study is to evaluate how the application of the calcium hydroxide paste after extraction of tooth affects alveolar bone formation. Methods:OSTEOINDUCTAL® is a calcium hydroxide pharmaceutical. Twenty-one Wistar rats were divided into two groups. In both groups, teeth were extracted. The control group under want no further treatment. OSTEOINDUCTAL® was applied after tooth extraction in the experimental group. The experimental animals were sacrificed for specimen preparation at 4 weeks and 8 weeks. After paraffin embedding, tissues were sliced and stained with H-E. From the each specimen, the proportions of the bone dimensions were calculated using a Micro Scope System ( MS-803, MORITEX, Tokyo, Japan ). Results:In the control group, the bone formation was slight at 4 postoperative weeks, and a pit formed by the invasion of the gingival connective tissue after extraction of the tooth lacuna was clearly present. In the experimental group, considerable new bone was formed. The experimental group had significantly more the proportions of the bone dimensions at 4 weeks (P<0.05). However, at 8 weeks, the defference between the control and the experimental groups was only slight. Conclusions:The results of this study suggest that the calcium hydroxide paste may speed up postoperative bone induction .