IADR Abstract Archives
Study of Platelet-rich Fibrin Intra-lock Implants in Wide and Regular Osteotomy Sites
Objectives: Implant placement in undersized osteotomies decreases implant micromovement and improves primary stability. With immediate implant placement in extraction sockets, limited research is available on using biologics to facilitate implant healing and shorten time for restoring patient form and function. This study tests the effectiveness ofplatelet-rich fibrin (PRF) with implants on the degree of osseointegration in regular and wide osteotomy sites.
Methods: Intra-Lock (Boca Raton, FL) implants were placed in the radius of beagle dogs. The experiment consisted of 4 groups: i) regular, ii) wide drilling, iii) regular + PRF and iv) wide + PRF. Blood was drawn from the specimen, centrifuged at ~30,000 RPM, after which the PRF was retrieved and placed into the osteotomy prior to implant insertion. Three in vivo points, 3-, 6-, and 12-weeks were evaluated. Samples were retrieved and subjected to histological processing for qualitative and quantitative analysis, via bone-to-implant contact (BIC) and bone-area-fraction occupation (BAFO).
Results: Quantitative analysis of BIC indicated a statistical difference between wide drilled groups at3 weeks; PRF had ~38% and nPRF had ~20%(p=0.03). Analysis of BAFO showed a statistical difference in wide drilled implant groups at the 3 week time point; PRF had ~56% and nPRF had ~20% (p=0.002). At 3 weeks, BIC and BAFO data from wide + PRF samples resembled wide nPRFsamples at 6-weeks. Qualitative analysis presented increased amounts of bone within the implant healing chambers in samples containing PRF, versus without PRF.
Conclusions: PRF may effectively factilitate implant healing in oversized sockets. Within wide osteotomies, this autologous material shows promise of increasing the overall osseointegration process by shortening the time to achieve substantial BIC and secondary stability. In patients with implants placed in immediate extraction sites, PRF presents a cost-effective, easy to obtain material that may improvelong-term desirable outcomes of implant placement.
Methods: Intra-Lock (Boca Raton, FL) implants were placed in the radius of beagle dogs. The experiment consisted of 4 groups: i) regular, ii) wide drilling, iii) regular + PRF and iv) wide + PRF. Blood was drawn from the specimen, centrifuged at ~30,000 RPM, after which the PRF was retrieved and placed into the osteotomy prior to implant insertion. Three in vivo points, 3-, 6-, and 12-weeks were evaluated. Samples were retrieved and subjected to histological processing for qualitative and quantitative analysis, via bone-to-implant contact (BIC) and bone-area-fraction occupation (BAFO).
Results: Quantitative analysis of BIC indicated a statistical difference between wide drilled groups at3 weeks; PRF had ~38% and nPRF had ~20%(p=0.03). Analysis of BAFO showed a statistical difference in wide drilled implant groups at the 3 week time point; PRF had ~56% and nPRF had ~20% (p=0.002). At 3 weeks, BIC and BAFO data from wide + PRF samples resembled wide nPRFsamples at 6-weeks. Qualitative analysis presented increased amounts of bone within the implant healing chambers in samples containing PRF, versus without PRF.
Conclusions: PRF may effectively factilitate implant healing in oversized sockets. Within wide osteotomies, this autologous material shows promise of increasing the overall osseointegration process by shortening the time to achieve substantial BIC and secondary stability. In patients with implants placed in immediate extraction sites, PRF presents a cost-effective, easy to obtain material that may improvelong-term desirable outcomes of implant placement.