Osseogate usage for Blood Glucose Level Measurements

Objectives: Titanium dental implants have been used successfully in restorative dentistry for more than 50 years in line with the great advances of bone biology. The speed of dissemination was overwhelming and the dental implants are currently considered as first options for restoring missing teeth. In this regard, it would be meaningful to think over what stage the titanium implants enter into from the perspective of technology life cycle and which direction we should take for further improvement or innovation in the future. As one unusual application of titanium implants, the Osseogate, the modified implant, will be introduced for the measurement of blood glucose level (BGL). In this animal experiments, the feasibility of the Osseogate usage for BGL measuremts was tested.

Methods: The traditional glucose oxidase methods using electrodes was incorporated into the Osseogate module, which can be considered fixed semi-permanent osseous blood circulation gateway. The electrodes were inserted the inner holes of Osseogate device and measure the BGL of the rabbits. Three New Zealand white rabbits were used and medial tibia metaphyseal regions were the site of implantation following the traditional literature.

Results: The BGL of the rabbit was measured four times a day with an interval of three hours. The comparison with the commercial self BGL measuring device showed a moderate to high coincidence.

Conclusions: With further development of measuring technology, the BGL measurements using Osseogates modules seemed feasible and promising.