Anti-erosion Benefit of Bioavailable Sn Dentifrice with and without Brushing

Objectives: To evaluate the erosion protection efficacy of a bioavailable Sn-containing NaF dentifrice relative to a negative control with and without the impact of tooth brushing.
Methods: The 10-day in-situ study utilized double blind, randomized, supervised-usage, two-treatment, parallel group, and split-mouth design. Sixty generally healthy subjects were enrolled into the study. Mandibular appliances containing 4 enamel specimens from caries-free extracted teeth were worn by the subjects. Treatments included a Sn-containing NaF dentifrice or a conventional NaF dentifrice, used 2x/day/30 seconds of lingual brushing, followed by 90 seconds of slurry exposure. Two specimens on one side of the mouth were brushed for 5 seconds each with an electric toothbrush. A total of 4 acid challenges using commercial orange juice was practiced everyday. Specimens were measured using non-contact profilometry. All statistical comparisons were two-sided at the 0.05 level of significance.

Results: All subjects completed the study. At Day 10 visit, the adjusted mean enamel surface loss was statistically significantly (p=0.022) lower for the Sn-containing NaF dentifrice group (5.607 µm) versus the control group (9.897 µm). For specimens exposed to slurry and brushing, the adjusted mean enamel loss was statistically significantly (p=0.048) lower for the Sn-containing NaF dentifrice group (6.678 µm) versus the control group (10.985 µm). For specimens exposed to slurry only, the adjusted mean enamel loss was statistically significantly (p=0.009) lower for the Sn-containing NaF dentifrice group (4.698 µm) relative to the control group (8.732 µm).
Conclusions: The study demonstrated significantly better erosion protection efficacy of the bioavailable Sn-containing NaF dentifrice under erosion and erosion/abrasion conditions.