IADR Abstract Archives
Assessment of Fluoride-release Pattern from Silver-diamine-fluoride and Fluoride-varnish
Objectives: Remineralization of enamel is enhanced in a system that has sustained fluoride release, allowing ions time to interact and build strong mineral. This study aims to compare the release pattern of fluoride from silver-diamine-fluoride (SDF) and fluoride-varnish (FV), using dynamic-salivary-flow model to simulate a clinical application.
Methods: Ten extracted human-teeth were sectioned mesiodistally to form 20 enamel-specimens. Specimens were randomly assigned into two groups (n=10), SDF and (FV) groups. 3x3 mm treatment-windows were created using acid-resistant nail varnish. Following treatment, specimens were submerged into artificial saliva following a Dynamic-Salivary-Model where artificial saliva was replaced with fresh saliva at 15-minutes, 30-minutes, 1-hour, 2-hours, 4-hours and 24-hours. Characterization of fluoride-release through fluoride ion concentration (ppm) was carried out using an Ion Selective Electrode.
Results: A two sample t-test was used to compare fluoride-release between SDF and FV at each time interval. At 15-minutes, the SDF-group showed a statistically significant greater fluoride-release (p<0.05). At 30-minutes, the FV-group showed a statistically significant greater fluoride-release. There were no statistically significant differences between both groups at the other time intervals (P<0.05). ANOVA test was used to determine if there was a statistically significant difference in fluoride-release over time for each treatment.
Conclusions: Within the limits of this study, SDF showed a faster initial release of fluoride compared to FV. Overall, there was no statistically significant difference in the release of fluoride between both groups. The release of fluoride ions decreases with time for both FV and SDF. Based on our results, we cannot determine whether there is better sustained fluoride-release in SDF when compared to FV. Thus, future experiments should examine the uptake of fluoride by teeth to better compare the effectiveness of both treatments.
Supported by Texas A&M Health Sciences and Baylor Oral Health Foundation (MTM).
Methods: Ten extracted human-teeth were sectioned mesiodistally to form 20 enamel-specimens. Specimens were randomly assigned into two groups (n=10), SDF and (FV) groups. 3x3 mm treatment-windows were created using acid-resistant nail varnish. Following treatment, specimens were submerged into artificial saliva following a Dynamic-Salivary-Model where artificial saliva was replaced with fresh saliva at 15-minutes, 30-minutes, 1-hour, 2-hours, 4-hours and 24-hours. Characterization of fluoride-release through fluoride ion concentration (ppm) was carried out using an Ion Selective Electrode.
Results: A two sample t-test was used to compare fluoride-release between SDF and FV at each time interval. At 15-minutes, the SDF-group showed a statistically significant greater fluoride-release (p<0.05). At 30-minutes, the FV-group showed a statistically significant greater fluoride-release. There were no statistically significant differences between both groups at the other time intervals (P<0.05). ANOVA test was used to determine if there was a statistically significant difference in fluoride-release over time for each treatment.
Conclusions: Within the limits of this study, SDF showed a faster initial release of fluoride compared to FV. Overall, there was no statistically significant difference in the release of fluoride between both groups. The release of fluoride ions decreases with time for both FV and SDF. Based on our results, we cannot determine whether there is better sustained fluoride-release in SDF when compared to FV. Thus, future experiments should examine the uptake of fluoride by teeth to better compare the effectiveness of both treatments.
Supported by Texas A&M Health Sciences and Baylor Oral Health Foundation (MTM).
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