IADR Abstract Archives
Properties of the Different Fluoride Salts Commonly Added to Toothpastes
Objectives: Sodium fluoride (NaF), sodium monofluorophosphate (MFP), stannous fluoride (SnF2) and amine fluorides (AmF) are salts usually added to toothpastes targeting to change these products of oral hygiene from cosmetics to therapeutics and the aim of this review is to present and discuss the properties of the different fluoride salts in terms of their social relevance and the benefits for oral health.
Methods: A search was conducted in LILACS, Medline and SciELO databases about the properties of fluoride salts used in toothpastes.
Results: The results are summarized on the table. NaF, SnF2 and AmF are fluoride salts not compatible with abrasive containing Ca usually used in toothpastes (CaCO3 or CaH2PO4.2H2O) because ion F (F-) is inactivated by ions Ca++ forming salts that are not bioavailable to be released in the oral cavity during toothbrushing. MFP is relatively compatible with abrasives containing Ca++ because fluoride is covalently bound to phosphate avoiding an inactivation when the toothpaste is manufactured, but during the storage the linkage is broken and F- released is inactivated by the abrasive. The advantage of MFP/CaCO3-based toothpaste is socio-economical because the costs of production is lower than other formulations using silica as abrasive. The challenge is to produce MFP/CaCO3-based toothpaste chemically stable during its expire time. NaF, SnF2, AmF and MFP present potential to interfere with caries development. SnF2 is the only fluoride salt that presents antigingivitis action because ion F or ion MFP do not have antiplaque effect. Regarding the effect against dental erosion, the most promissing fluoride salt is SnF2 because there is synergism between the effect of stannous products acid-resistant formed on dental surface with the remineralizing effect of ion F. MFP does not have antierosive effect because ion MFP (PO3F2-) does not have remineralizing power.
Conclusions: All fluoride salts used in toothpastes present potential to interfere with caries but only MFP and SnF2 present unique others properties.
Methods: A search was conducted in LILACS, Medline and SciELO databases about the properties of fluoride salts used in toothpastes.
Results: The results are summarized on the table. NaF, SnF2 and AmF are fluoride salts not compatible with abrasive containing Ca usually used in toothpastes (CaCO3 or CaH2PO4.2H2O) because ion F (F-) is inactivated by ions Ca++ forming salts that are not bioavailable to be released in the oral cavity during toothbrushing. MFP is relatively compatible with abrasives containing Ca++ because fluoride is covalently bound to phosphate avoiding an inactivation when the toothpaste is manufactured, but during the storage the linkage is broken and F- released is inactivated by the abrasive. The advantage of MFP/CaCO3-based toothpaste is socio-economical because the costs of production is lower than other formulations using silica as abrasive. The challenge is to produce MFP/CaCO3-based toothpaste chemically stable during its expire time. NaF, SnF2, AmF and MFP present potential to interfere with caries development. SnF2 is the only fluoride salt that presents antigingivitis action because ion F or ion MFP do not have antiplaque effect. Regarding the effect against dental erosion, the most promissing fluoride salt is SnF2 because there is synergism between the effect of stannous products acid-resistant formed on dental surface with the remineralizing effect of ion F. MFP does not have antierosive effect because ion MFP (PO3F2-) does not have remineralizing power.
Conclusions: All fluoride salts used in toothpastes present potential to interfere with caries but only MFP and SnF2 present unique others properties.