IADR Abstract Archives
Remineralizing Copper Doped Phosphate Glass-Polyacrylate Paste for Biomimetic Dentin Repair
Objectives: Objectives: The objective of this study was to investigate the remineralizing potential of an experimental paste based on degradable phosphate glass and polyacrylic acid
Methods: Methods: 1 mm thick human dentin discs were etched with 37% phosphoric acid for 5hrs and treated with the experimental paste for 1 to 8 weeks. The remineralization was assessed by scanning electron microscopy/Energy Dispersive X-ray (SEM/EDX) and optical coherence tomography (OCT). Untreated etched dentin was used as a control.
Results: Results: Etching regime used in this study produced a surface demineralized layer of 120±30 mm; subsurface demineralization layer of 100-300 mm was also observed. After treatment with the experimental paste for 1 week, remineralization of dentin was observed. The depth of the remineralized layer was 60±23 mm; this layer, however, appears inhomogeneous, with several pitted and frayed areas. Increasing the treatment time increases the depth of remineralization; the remineralized layer became fairly homogenous but varies in thickness across the entire dentin. The thickness of the remineralized layer reaches 313±6 mm after 8 weeks. As detected from EDX analysis, the intensity of phosphate (P) increased after treatment with the experimental paste; copper (Cu) was also detected in dentin and its intensity increased with time.
Conclusions:
Conclusions: This experimental paste could be potentially used in remineralizing dentin produced by caries or acid etching particularly in areas where adhesives fail to penetrate.
Methods: Methods: 1 mm thick human dentin discs were etched with 37% phosphoric acid for 5hrs and treated with the experimental paste for 1 to 8 weeks. The remineralization was assessed by scanning electron microscopy/Energy Dispersive X-ray (SEM/EDX) and optical coherence tomography (OCT). Untreated etched dentin was used as a control.
Results: Results: Etching regime used in this study produced a surface demineralized layer of 120±30 mm; subsurface demineralization layer of 100-300 mm was also observed. After treatment with the experimental paste for 1 week, remineralization of dentin was observed. The depth of the remineralized layer was 60±23 mm; this layer, however, appears inhomogeneous, with several pitted and frayed areas. Increasing the treatment time increases the depth of remineralization; the remineralized layer became fairly homogenous but varies in thickness across the entire dentin. The thickness of the remineralized layer reaches 313±6 mm after 8 weeks. As detected from EDX analysis, the intensity of phosphate (P) increased after treatment with the experimental paste; copper (Cu) was also detected in dentin and its intensity increased with time.
Conclusions:
Conclusions: This experimental paste could be potentially used in remineralizing dentin produced by caries or acid etching particularly in areas where adhesives fail to penetrate.