IADR Abstract Archives
In Vitro Lubricity and Moisture Retention of Xerostomia Sprays
Objectives: To compare in vitro lubricity and moisture retention of xerostomia sprays: oxidized glycerol triester (OGT)-based 3M™ Xerostomia Relief Spray (XRS), Biotène® Moisturizing Spray (BS), and an experimental xerostomia spray (EXP).
Methods: As a model of lubricity in the mouth, a friction coefficient was measured using a ForceBoard™ friction tester (Industrial Dynamics) at a vertical force of 3N with 0.5-ml test solution between two mucosal mimic substrates (rinsed TROJAN™ Naturalamb™ sheep cecum condoms). Water was used as a control. Moisture retention was measured using a LECO® TGA701 thermogravimetric analyzer (TGA). Samples of sliced (6-mm thick, 10-mm diameter) raw beef sirloin were immersed in test solutions and placed in the TGA. Tissues were obtained from a packing plant/slaughter house. The samples were held at 37°C for 4 hours, and the % volatiles (water) lost were recorded. The temperature was then increased to burn off all volatile materials and obtain the total % weight loss. The % weight lost at 4 hours was divided by the total % weight loss and expressed as a percentage (% of total water lost at 4 hours). Untreated beef was used as a control.
Results: The table shows mean ± standard deviation for friction coefficient and % of total water lost at 4 hours. Letters in column “SND Groups” denote groups that are statistically not different (SND) via ANOVA with Tukey's t-test (p>0.05).
Conclusions: XRS has improved lubricity and moisture retention compared to BS and EXP. BS and EXP have comparable lubricity but EXP has superior moisture retention compared to BS.
Methods: As a model of lubricity in the mouth, a friction coefficient was measured using a ForceBoard™ friction tester (Industrial Dynamics) at a vertical force of 3N with 0.5-ml test solution between two mucosal mimic substrates (rinsed TROJAN™ Naturalamb™ sheep cecum condoms). Water was used as a control. Moisture retention was measured using a LECO® TGA701 thermogravimetric analyzer (TGA). Samples of sliced (6-mm thick, 10-mm diameter) raw beef sirloin were immersed in test solutions and placed in the TGA. Tissues were obtained from a packing plant/slaughter house. The samples were held at 37°C for 4 hours, and the % volatiles (water) lost were recorded. The temperature was then increased to burn off all volatile materials and obtain the total % weight loss. The % weight lost at 4 hours was divided by the total % weight loss and expressed as a percentage (% of total water lost at 4 hours). Untreated beef was used as a control.
Results: The table shows mean ± standard deviation for friction coefficient and % of total water lost at 4 hours. Letters in column “SND Groups” denote groups that are statistically not different (SND) via ANOVA with Tukey's t-test (p>0.05).
Conclusions: XRS has improved lubricity and moisture retention compared to BS and EXP. BS and EXP have comparable lubricity but EXP has superior moisture retention compared to BS.