IADR Abstract Archives
Community Co-Localization of Oral Health and Aerodigestive and Oral Cancers
Objectives: This study highlights the relationship between poor oral health and oral, head and neck squamous cell carcinoma, lung and colorectal carcinomas. These cancers have a common etiology and compose upper aerodigestive tract cancers (UADTCs), which show increased incidence and death rates for Black males in Chicago county and community areas (CAs).
Methods: Data from Illinois Cancer Registry, CDC, NIH/NCI SEER, National Center for Health Statistics, zip code/census for geodemographic information, and Chicago Health Atlas 2.0 provide cancer statistics. UIC College of Dentistry AxiUm records, with Oral Health Foundation findings, indicate tooth and periodontal condition. Statistics used were multivariate analysis (ANOVA), Spearman ranking, regression analysis and a representative dendrogram of relative incidence and mortality rates.
Results: Dendrogram analysis of 15 counties in Illinois for incidence of UADTC (0.78-0.66) showed clustering of incidence and mortality rates for UADTCs in Cook County with higher than national levels for 47 CAs in Chicago. These statistics appear to be consistent with other large Midwest cities. CAs designated high risk (HR) show total population UADTC rates of: 67.1-201.7 per 10,000, with male populations showing: 75.9-247.6 per 10,000. These CAs predominant with non-Hispanic Blacks: 83.3+/-19.6%. Low Risk (LR) CA total population UADTC rates show: 28.2-67.0 per 10,000, with male populations showing: 30.2-75.8 per 10,000. LR CAs have predominantly Hispanic or non-Hispanic white populations. Significant differences between HR and LR UADTC incidence rates were p=0.0001; OR=2.244, and RR=2.173, at CI p-value=0.0021. 8642 records from subjects that reside in HR and LR CAs showed significant (p=0.0001) differences in periodontal disease; missing teeth and fewer surfaces restored. Moreover, HR CAs (84%) provided oral carcinomas that expressed 31 miRNAs (16.4-87.3x increase over baseline).
Conclusions: In Chicago CAs, poor oral health, specifically among Black males, is associated with UADTC incidence, mortality rates, and molecular expressions.
Methods: Data from Illinois Cancer Registry, CDC, NIH/NCI SEER, National Center for Health Statistics, zip code/census for geodemographic information, and Chicago Health Atlas 2.0 provide cancer statistics. UIC College of Dentistry AxiUm records, with Oral Health Foundation findings, indicate tooth and periodontal condition. Statistics used were multivariate analysis (ANOVA), Spearman ranking, regression analysis and a representative dendrogram of relative incidence and mortality rates.
Results: Dendrogram analysis of 15 counties in Illinois for incidence of UADTC (0.78-0.66) showed clustering of incidence and mortality rates for UADTCs in Cook County with higher than national levels for 47 CAs in Chicago. These statistics appear to be consistent with other large Midwest cities. CAs designated high risk (HR) show total population UADTC rates of: 67.1-201.7 per 10,000, with male populations showing: 75.9-247.6 per 10,000. These CAs predominant with non-Hispanic Blacks: 83.3+/-19.6%. Low Risk (LR) CA total population UADTC rates show: 28.2-67.0 per 10,000, with male populations showing: 30.2-75.8 per 10,000. LR CAs have predominantly Hispanic or non-Hispanic white populations. Significant differences between HR and LR UADTC incidence rates were p=0.0001; OR=2.244, and RR=2.173, at CI p-value=0.0021. 8642 records from subjects that reside in HR and LR CAs showed significant (p=0.0001) differences in periodontal disease; missing teeth and fewer surfaces restored. Moreover, HR CAs (84%) provided oral carcinomas that expressed 31 miRNAs (16.4-87.3x increase over baseline).
Conclusions: In Chicago CAs, poor oral health, specifically among Black males, is associated with UADTC incidence, mortality rates, and molecular expressions.