The Influence of Leukocyte-Platelet-Rich Plasma on The Tooth Movement

Objectives: To evaluate the influence of leukocyte-platelet-rich plasma (L-PRP) on the tooth inclination after orthodontic tooth movement in a rabbit model.
Methods: Fifteen male New Zealand white rabbits were used to conduct the experiment study with a split-mouth design. The maxillary first premolars were mesially moved with 100-gram nickel-titanium closed-coil spring. One side of maxilla were randomly assigned to receive L-PRP injection, while the contralateral side serving as its control received normal saline. Injection areas were submucosally administered at the buccal and lingual areas of the first premolar. The tooth inclination of the first premolar was measured by microcomputed tomography (micro-CT) at days 0, 14 and 28.
Results: The intergroup comparison revealed no statistically significant differences between L-PRP and control groups at all periods of observations (P>0.05) but in the intragroup analysis, statistically significant differences were observed within each group between periods of observations (P<0.05).
Conclusions: L-PRP injection did not influence the tooth inclination in term of mesial tipping after orthodontic tooth movement when compared with control group.