Efficacy of CPP-ACP on Bleaching Related Sensitivity: Randomized Clinical Trial

Objectives: The purpose of this randomized controlled, split mouth clinical trial was to evaluate the effectiveness of MI paste in reducing sensitivity associated vital bleaching.
Methods: 45 subjects were recruited following IRB approval. Subjects were randomly divided into two groups, based upon which arch received MI paste. Group 1 bleached Maxillary arch Group 2 bleached mandibular arch. Two weeks later Subject stopped bleaching first arch and were provided two trays for the second arch. Subjects were instructed to use MI paste (GC America) in the non-scalloped tray for 5 minutes on second arch , wait for 1 hour and then bleach using the second scalloped tray. Sensitivity was measured by VAS daily log scale at baseline and daily for the two weeks. Shade was taken with colorimeter Shade Vision and Classic Vita shade guide at baseline, immediate post-bleaching, and two weeks post-bleaching. Longitudinal sensitivity experience over the 14 days period of bleaching was summarized using trapezoidal area. The Wilcoxon Signed Rank test was used to compare summary measures between the arch allocations.
Results: A significant reduction (p=0.005) in sensitivity scores in the arch using the MI paste versus compared to no MI paste was found. The mean trapezoidal area for the 14-day period treated without MI paste was 38.1 and for the arch treated with MI Paste were 27.8. No evidence of interaction between treatment and arch allocation was found (p=0.78), nor was there any indication of a baseline difference in VAS scores between arches. Both arches with or without the use of MI Paste showed significant shade change relative to baseline regardless of arch allocation group (p<0.0001).
Conclusions: MI paste significantly reduced the sensitivity associated with bleaching and did not interfere with shade change.