Genotoxicity and Anti inflammatory activity of Linalool on Oral Cancer

Objectives: This study aims to assess the genotoxicity and anti inflammatory activity of Linalool on oral cancer cell lines
Methods: Coriandrum Sativum major constituent Linalool (+/- 3, 7-Dimethyl-1, 6-octadien-3-ol) was procured from Sigma-Aldrich. HRBC membrane stabilization method and OSCC cell lines were acquired from NCCS-Pune, India. The Sample was used to assess various factors involved in anti-inflammatory and genotoxicity potentials in OSCC cell lines. The assays were done by using spectrophotometer and agarose gel electrophoresis techniques.

Results: There is a significant decrease (P<0.05) in % of haemolysis, as well as highly significant increase (p<0.005) in % of protection seen in Linalool treatment when compared with the positive control Diclofenac. DNA isolated from OSCC cell lines with 3 different concentration of Linalool added, was then subjected to analyze for the fragmentation. In agarose gel electrophoresis studies, it has shown a prominent evidence for the DNA fragmentation related to apoptosis in cancer cells.
Conclusions: Our study states that there is very high anti inflammatory activity and moderate genotoxicity effects of Linalool which proves that Coriandrum Sativum can be used as a natural or herbal medicine to cure inflammation and to control cancer related problems. This should be considerd in modern medicine to overcome the side effects of synthetic medicine used for inflammation and cancer.