IADR Abstract Archives
Dental Aspects of Multiple Myeloma
Objectives: Multiple myeloma (MM) is a blood dyscrasia associated with malignant plasma cells, producing monoclonal immunoglobulins (Igs). Its oral manifestations are often overlooked as pathological Igs invade multiple organs, causing various symptoms. MM lesions in the jaw can be seen in approximately 5-30% of cases and in about of 14 % of these are the first sign of the disease. Immunosuppressive treatment of MM has many side effects on oral health status, hence understanding MM's connection with dentistry can refine treatment plan. Accordingly, we wished to evaluate disease impact on the general upkeep of oral health before and after treatment as well as compare MM patients' oral health status and that of a control group of patients free from any malignant disease.
Methods: Patient examination was performed 2016.October 1st - 2017. June 23rd at University of Debrecen Faculty of Dentistry Dental Outpatient Department. Comparative examination of patients' cariodontal and periodontal status was done on 12 MM patients following autologous peripherial stem cell transplantation (APSCT) and 10 control patients. Data were recorded using University of Bern School of dentistry periodontal chart and DMFT index ( D-decayed; M-missing; F-filled; T-tooth) .
Results: Average age of the control group was 66,00±3,6 years and 62,8±4,9 in the MM group with the latter showing better result in any index value, bleeding on probing index being the most significant one.
Conclusions: Based on results we can conclude that MM patients’ dental status that had undergone APSCT was significantly better than control group’s patients’. One explanation can be that patients before APSCT need a complete removal of dental focal infections, leading to good oral hygiene status, which in-turn could compensate for the negative effects of immunosuppressant treatment on oral status.
Methods: Patient examination was performed 2016.October 1st - 2017. June 23rd at University of Debrecen Faculty of Dentistry Dental Outpatient Department. Comparative examination of patients' cariodontal and periodontal status was done on 12 MM patients following autologous peripherial stem cell transplantation (APSCT) and 10 control patients. Data were recorded using University of Bern School of dentistry periodontal chart and DMFT index ( D-decayed; M-missing; F-filled; T-tooth) .
Results: Average age of the control group was 66,00±3,6 years and 62,8±4,9 in the MM group with the latter showing better result in any index value, bleeding on probing index being the most significant one.
Conclusions: Based on results we can conclude that MM patients’ dental status that had undergone APSCT was significantly better than control group’s patients’. One explanation can be that patients before APSCT need a complete removal of dental focal infections, leading to good oral hygiene status, which in-turn could compensate for the negative effects of immunosuppressant treatment on oral status.