IADR Abstract Archives
Kinetic Barrier Membrane Performance of Two Standard Collagen Membranes
Objectives: The objective of the present study was to show that a porcine pericardium collagen membrane (botiss Jason® membrane) applied to a bone substitute-grafted defect is suitable to inhibit soft tissue ingrowth for at least 3 months.
Methods: 18 adult male Yucatan minipigs with age of 20 - 24 months were included in the study. Lower premolars P2, P3, P4 and first molar M1 were extracted bilaterally. Following 4 month of healing 4 semi-saddle bone defects were created per mandible, filled with two bovine xenografts respectively (BioOss® or Cerabone®) and covered with the respective collagen membranes (Bio-Gide® or Jason®). The 18 operated animals were sacrificed and split into 3 groups : 6 animals per time point at 4, 8 and 12 weeks of healing. The mandibles were retrieved for histological processing. Microscopic observation and measurements of the residual membrane across the buccopalatal cross-section of the defects were done.
Results: Histologic micrographs of experimental groups revealed residual membrane presence at all time points in vivo. Ranked residual membrane as a function of time demonstrated significant degradation after 12 weeks in vivo relative to 4 weeks (p = 0.017), without significant difference between 4 and 8 weeks (p = 0.147). Data as a function of experimental groups depicted absence of significant difference between membrane types irrespective grafting material (p > 0.093).
Conclusions: The examined porcine pericardium collagen membrane is statistically non-inferior to the control collagen membrane in terms of barrier function and resorption kinetics. The barrier function remained intact up to 12 weeks in vivo in the present model. These data suggest that the examined pericardium membrane begins to undergo significant degradation between 8 and 12 weeks, which appears to be sufficient to allow a concerted bone healing process to occur
Methods: 18 adult male Yucatan minipigs with age of 20 - 24 months were included in the study. Lower premolars P2, P3, P4 and first molar M1 were extracted bilaterally. Following 4 month of healing 4 semi-saddle bone defects were created per mandible, filled with two bovine xenografts respectively (BioOss® or Cerabone®) and covered with the respective collagen membranes (Bio-Gide® or Jason®). The 18 operated animals were sacrificed and split into 3 groups : 6 animals per time point at 4, 8 and 12 weeks of healing. The mandibles were retrieved for histological processing. Microscopic observation and measurements of the residual membrane across the buccopalatal cross-section of the defects were done.
Results: Histologic micrographs of experimental groups revealed residual membrane presence at all time points in vivo. Ranked residual membrane as a function of time demonstrated significant degradation after 12 weeks in vivo relative to 4 weeks (p = 0.017), without significant difference between 4 and 8 weeks (p = 0.147). Data as a function of experimental groups depicted absence of significant difference between membrane types irrespective grafting material (p > 0.093).
Conclusions: The examined porcine pericardium collagen membrane is statistically non-inferior to the control collagen membrane in terms of barrier function and resorption kinetics. The barrier function remained intact up to 12 weeks in vivo in the present model. These data suggest that the examined pericardium membrane begins to undergo significant degradation between 8 and 12 weeks, which appears to be sufficient to allow a concerted bone healing process to occur