Kinetic Barrier Membrane Performance of Two Standard Collagen Membranes
Objectives: The objective of the present study was to show that a porcine pericardium collagen membrane (botiss Jason® membrane) applied to a bone substitute-grafted defect is suitable to inhibit soft tissue ingrowth for at least 3 months. Methods: 18 adult male Yucatan minipigs with age of 20 - 24 months were included in the study. Lower premolars P2, P3, P4 and first molar M1 were extracted bilaterally. Following 4 month of healing 4 semi-saddle bone defects were created per mandible, filled with two bovine xenografts respectively (BioOss® or Cerabone®) and covered with the respective collagen membranes (Bio-Gide® or Jason®). The 18 operated animals were sacrificed and split into 3 groups : 6 animals per time point at 4, 8 and 12 weeks of healing. The mandibles were retrieved for histological processing. Microscopic observation and measurements of the residual membrane across the buccopalatal cross-section of the defects were done. Results: Histologic micrographs of experimental groups revealed residual membrane presence at all time points in vivo. Ranked residual membrane as a function of time demonstrated significant degradation after 12 weeks in vivo relative to 4 weeks (p = 0.017), without significant difference between 4 and 8 weeks (p = 0.147). Data as a function of experimental groups depicted absence of significant difference between membrane types irrespective grafting material (p > 0.093). Conclusions: The examined porcine pericardium collagen membrane is statistically non-inferior to the control collagen membrane in terms of barrier function and resorption kinetics. The barrier function remained intact up to 12 weeks in vivo in the present model. These data suggest that the examined pericardium membrane begins to undergo significant degradation between 8 and 12 weeks, which appears to be sufficient to allow a concerted bone healing process to occur
IADR/PER General Session
2018 IADR/PER General Session (London, England) London, England
2018 0119 Dental Materials 5: Biocompatibility, Bioengineering and Biologic Effects of Materials
Bornert, Fabien
( University of Strasbourg
, Strasbourg
, France
; University Hospital of Strasbourg
, Strasbourg
, France
; INSERM (French National Institute of Health and Medical Research)
, Strasbourg
, France
)
Sandgren, Rebecca
( Lund University, Biomedical Center
, Lund
, Sweden
)
Bellón, Benjamin
( Institut Straumann AG
, Basel
, Switzerland
)
Pippenger, Benjamin
( Institut Straumann AG
, Basel
, Switzerland
)
Shahdad, Shakeel
( Queen Mary University of London
, London
, United Kingdom
)
This study was funded by Institut Straumann AG.
This study was funded by Institut Straumann AG. Benjamin Pippenger and Benjamin Bellón are employed by Institut Straumann AG.
Oral Session
Implant Surface Technology, Grafting Materials and Cements for Bone Regeneration
Wednesday,
07/25/2018
, 09:30AM - 11:00AM