The Study on Salivary Secretion in Allergic Rhinitis Symptom Improvement

Objectives: It has been shown that mucosal immunity via salivary IgA may contribute to an improvement of pollen symptoms. Allergic symptomatic relief was reported to patients wearing Night Guard (NG), and it was suggested that suppression of antigen adhesion and inhibition of adhesion of mast cell anti-IgE antibody by secretion of secretory IgA by increasing saliva flow rate.

Methods: It was analyzed the correlation between saliva flow rate before and after fitting NG, amount of Ig A in saliva and allergic symptoms. Subjects in February 2016 - May 2017 visited our university pollen using 30 subjects and 8 healthy subjects as the control group, saliva flow rate, and saliva IgA concentration before and after NG was measured by ELISA method (UMIN000026428). Allergic rhinitis symptoms of hay fever were examined according to severity classification.

Results: Rhinitis severity classification before and after NG was significantly improved before and after NG. As a result of measuring the saliva flow rate, it was significantly increased before and after NG. It was revealed that salivary IgA secretion concentration was significantly decreased in hay fever patients.
Conclusions: NG used for dental care showed the possibility of alleviating symptoms of allergic rhinitis caused by pollinosis by increasing saliva amount and salivary IgA secretion rate.