IADR Abstract Archives
A Versatile Poly(methyl methacrylate) Cement Functionalized With Quaternized Chitosan-glycerophosphate/hydroxyapatite Hydrogels
Objectives: To design a more versatile version of PMMA cement with adorable properties to target drawbacks for future clinical application
Methods: We synthesized a modified version by combining PMMA with quaternized chitosan (N-(2-hydroxy)propyl-3-trimethylammonium chitosan chloride, HTCC)-based hydrogels loaded with nanosized hydroxyapatite (Nano-HA). Then, the physicochemical properties, antimicrobial properties, remineralization capacity and mechanical performance changes under imitated physiological conditions were tested for these cements using a type K thermocouple, scanning electron microscope (SEM), microcomputed tomography (µ-CT), calcium ion test kit and mechanical compression tests.
Results: The results showed that the HTCC-GP thermosensitive hydrogel lowered the Tmax value, lengthened the working time, generated interconnected pores, developed appropriate mechanical properties and imparted excellent antibacterial activity to the cement. The Nano-HA particles engendered improved biomineralization ability of the cements without adversely influencing the mechanical performance.
Conclusions: Results indicated that the injectable and multifunctional cement resulting from the p-PMMA/HTCC-GP/Nano-HA combination holds strong promise for future bone reconstruction applications.
Methods: We synthesized a modified version by combining PMMA with quaternized chitosan (N-(2-hydroxy)propyl-3-trimethylammonium chitosan chloride, HTCC)-based hydrogels loaded with nanosized hydroxyapatite (Nano-HA). Then, the physicochemical properties, antimicrobial properties, remineralization capacity and mechanical performance changes under imitated physiological conditions were tested for these cements using a type K thermocouple, scanning electron microscope (SEM), microcomputed tomography (µ-CT), calcium ion test kit and mechanical compression tests.
Results: The results showed that the HTCC-GP thermosensitive hydrogel lowered the Tmax value, lengthened the working time, generated interconnected pores, developed appropriate mechanical properties and imparted excellent antibacterial activity to the cement. The Nano-HA particles engendered improved biomineralization ability of the cements without adversely influencing the mechanical performance.
Conclusions: Results indicated that the injectable and multifunctional cement resulting from the p-PMMA/HTCC-GP/Nano-HA combination holds strong promise for future bone reconstruction applications.