IADR Abstract Archives
Novel CPC-Clay Toothpaste and Extrinsic Tooth Stain
Objectives: To evaluate the effect of toothpaste containing cetylpyridinium chloride- clay (CPC-clay) on extrinsic tooth stain.
Methods: An in vitro method was used to assess staining potential of 1.5% CPC-clay toothpaste versus control toothpaste without CPC-clay. The study was conducted as follows: teeth incubated in saliva à treated with test product slurries à incubated in saliva à exposed to a freshly made tea solution à rinsed and incubated in saliva. A total of six cycles were performed. L*a*b* colour values were taken, by chromameter, before and after treatment and changes in the individual components (△values) calculated. The total colour change (△E) was calculated as the square root of the sum of the squares of the △ values.
In-vivo assessment was accomplished through a randomised, single blind, parallel design study (n=128) comparing 1.5% CPC-clay toothpaste to two marketed fluoride toothpastes. Extrinsic tooth stain was assessed at baseline and after 3 and 6 weeks of twice daily product use, using Macpherson modification of Lobene stain index.
Results: ANCOVA analysis on log transformed values with Turkey adjustment showed no statistically significant differences between CPC-Clay toothpaste and marketed products at 3 or 6 week timepoint (p>0.95).
*Different letters differ significantly at p<0.05.
Conclusions: There was no evidence from these in vitro and in vivo studies that CPC-clay toothpaste gave higher levels of extrinsic tooth stain than standard fluoride toothpaste, suggesting that the clay in the formulation helps overcome the potential staining effects of CPC.
Methods: An in vitro method was used to assess staining potential of 1.5% CPC-clay toothpaste versus control toothpaste without CPC-clay. The study was conducted as follows: teeth incubated in saliva à treated with test product slurries à incubated in saliva à exposed to a freshly made tea solution à rinsed and incubated in saliva. A total of six cycles were performed. L*a*b* colour values were taken, by chromameter, before and after treatment and changes in the individual components (△values) calculated. The total colour change (△E) was calculated as the square root of the sum of the squares of the △ values.
In-vivo assessment was accomplished through a randomised, single blind, parallel design study (n=128) comparing 1.5% CPC-clay toothpaste to two marketed fluoride toothpastes. Extrinsic tooth stain was assessed at baseline and after 3 and 6 weeks of twice daily product use, using Macpherson modification of Lobene stain index.
Results: ANCOVA analysis on log transformed values with Turkey adjustment showed no statistically significant differences between CPC-Clay toothpaste and marketed products at 3 or 6 week timepoint (p>0.95).
*Different letters differ significantly at p<0.05.
Conclusions: There was no evidence from these in vitro and in vivo studies that CPC-clay toothpaste gave higher levels of extrinsic tooth stain than standard fluoride toothpaste, suggesting that the clay in the formulation helps overcome the potential staining effects of CPC.