The Expression of Notch Signaling Pathway Molecules in SAMP8 Tongue

Objectives: Notch signaling may the effects of vascular aging. The aim of the study is to investigate notch signaling (Notch 3), vascular and neurogenesis markers mRNAs such as functional different property in the mouse anterior and posterior regions tongue of senescence-accelerated prone mice (SAMP8).
Methods: We investigate mRNA of Notch 3, VEGF, CGRP, CD31, LYVE-1, NGF and neuropeptide in SAMP8 and senescence-accelerated resistant mouse (SAMR1) tongue at 12 and 24 weeks of age using real-time RT-PCR mRNA analyses and in situ hybridization.
Results: The abundance of Notch 3 mRNA increased in contrast to decreased NGF, neuropeptide, CD31 and LYVE-1 mRNAs of the anterior region of SMP8 tongue between 12-week-old and 24-week-old SAMP8 compared to that of SAMR1 (p<0.01).
Conclusions: Notch pathway may be activated in tongue at vascular and nerve signal levels in our results during aging. These findings implicate a potential involvement of Notch signaling in vascular and nerve aging in tongue functional properties.