IADR Abstract Archives
Clinical Efficacy on Tooth Sensitivity Relief of Elmex Sensitive Toothpaste
Objectives: To compare the clinical efficacy of test toothpaste containing 1400 ppm F as amine fluoride and a specially-designed silica (test) to a toothpaste containing 1400 ppm F as sodium fluoride and regular silica (negative control) on dentinal hypersensitivity after brushing twice daily (morning and evening) for 8 weeks.
Methods: Prior to the study the clinical protocol was reviewed and approved by IRB. The study had a randomized, double-blind, parallel-group design. Subjects with two hypersensitivity teeth (tactile score: 10-50 g; air blast score: 2-3), participated in the study. They brushed 2X daily with their assigned toothpaste and were assessed using tactile and air blast indices at baseline, 4 and 8 weeks. All statistical tests of hypotheses were two sided, and employed a level of significance of a=0.05.
Results: A total of 80 subjects completed the study. At baseline, no statistically significant (p>0.05) differences in the tactile and air blast scores between the test and negative control groups were indicated. At 4 weeks the test and negative control groups showed tactile scores of 20.81 and 12.14, respectively; and air blast scores of 1.31 and 2.28, respectively. The test group provided statistically significantly (p<0.05) greater reductions in dentinal hypersensitivity than the negative control group (tactile: 71.4% and air blast: 42.5%). At 8 weeks the test and negative control groups showed tactile scores of 32.14 and 12.73, respectively; and air blast scores of 0.75 and 2.29, respectively. The test group provided statistically significantly (p<0.05) greater reductions in hypersensitivity than the negative control group (tactile: 152.5% and air blast: 67.2%).
Conclusions: The study results demonstrated that test toothpaste containing 1400 ppm F as amine fluoride and a specially-designed silica provides significant reductions in tactile and air blast hypersensitivity as compared to a toothpaste containing 1400 ppm F as sodium fluoride and regular silica after 4 and 8 weeks of product use.
Methods: Prior to the study the clinical protocol was reviewed and approved by IRB. The study had a randomized, double-blind, parallel-group design. Subjects with two hypersensitivity teeth (tactile score: 10-50 g; air blast score: 2-3), participated in the study. They brushed 2X daily with their assigned toothpaste and were assessed using tactile and air blast indices at baseline, 4 and 8 weeks. All statistical tests of hypotheses were two sided, and employed a level of significance of a=0.05.
Results: A total of 80 subjects completed the study. At baseline, no statistically significant (p>0.05) differences in the tactile and air blast scores between the test and negative control groups were indicated. At 4 weeks the test and negative control groups showed tactile scores of 20.81 and 12.14, respectively; and air blast scores of 1.31 and 2.28, respectively. The test group provided statistically significantly (p<0.05) greater reductions in dentinal hypersensitivity than the negative control group (tactile: 71.4% and air blast: 42.5%). At 8 weeks the test and negative control groups showed tactile scores of 32.14 and 12.73, respectively; and air blast scores of 0.75 and 2.29, respectively. The test group provided statistically significantly (p<0.05) greater reductions in hypersensitivity than the negative control group (tactile: 152.5% and air blast: 67.2%).
Conclusions: The study results demonstrated that test toothpaste containing 1400 ppm F as amine fluoride and a specially-designed silica provides significant reductions in tactile and air blast hypersensitivity as compared to a toothpaste containing 1400 ppm F as sodium fluoride and regular silica after 4 and 8 weeks of product use.