Objectives: SOX-2 is a transcription factor involved in maintaining the pluripotency of embryonic cells and some adult stem cells and, in cancer cells in the proliferation, tumorigenicity, chemoresistance, and metastasis. However, the function of SOX-2 in Oral Leucoplakia, classified by Binary System was not studied. The objective of the study was evaluate the SOX-2 expression of in Oral Leukoplakia. Methods: Sixty seven cases of Oral Leucoplakia (34 low risk and 33 high risk of dysplasia, and 25 controls were submitted to immunohistochemistry with SOX-2. In the epithelium, the immunopositive nuclear area was measure by semiautomatic segmentation. One-way analysis of variance, and Games-Howell tests were performed. Results: Oral Leucoplakia (low and high risk) presented higher positive nuclear area (0.24 ± 0.47 vs 1.09 ± 2.06) compared to the control group (0.00 ± 0.01) (p = 0.01). Conclusions: The overexpression of SOX-2 in Oral Leukoplakia may be involved with the development of this lesion.
Division: IADR/PER General Session
Meeting:2018 IADR/PER General Session (London, England) Location: London, England
Year: 2018 Final Presentation ID:1082 Abstract Category|Abstract Category(s):Oral Medicine & Pathology Research
Authors
Luiz, Suelen
( Pontifícia Universidade Católica do Paraná
, Curitiba
, Brazil
)
Trindade Grégio Hardy, Ana Maria
( Pontifícia Universidade Católica do Paraná
, Curitiba
, Brazil
)
Scariot, Rafaela
( Universidade Positivo
, Curitiba
, Parana
, Brazil
)
Aguiar, Maria
( UFMG
, Belo Horizonte
, Brazil
)
Aparecido Ignácio, Sérgio
( Pontifícia Universidade Católica do Paraná
, Curitiba
, Brazil
)
Jham, Bruno
( College of Dental Medicine – Illinois | Midwestern University
, Illinois
, Illinois
, United States
)
Johann, Aline
( Pontifícia Universidade Católica do Paraná
, Curitiba
, Brazil
)
De Noronha, Lucia
( Pontifícia Universidade Católica do Paraná
, Curitiba
, Brazil
)
Siqueira, Filipe
( UFSC
, Florianópolis
, Brazil
)
Mozzer, Izabela
( Pontifícia Universidade Católica do Paraná
, Curitiba
, Brazil
)
Santos, Emanuela
( Pontifícia Universidade Católica do Paraná
, Curitiba
, Brazil
)
Nagashima, Seigo
( Pontifícia Universidade Católica do Paraná
, Curitiba
, Brazil
)
Paula Camargo Martins, Ana
( Pontifícia Universidade Católica do Paraná
, Curitiba
, Brazil
)
Luise Viola De Azevedo, Marina
( Pontifícia Universidade Católica do Paraná
, Curitiba
, Brazil
)
Reis Azevedo Alanis, Luciana
( Pontifícia Universidade Católica do Paraná
, Curitiba
, Brazil
)
Support Funding Agency/Grant Number: This study received financial support from the National Council for Scientific and Technological Development (CNPq, #457859/2014-8).
Financial Interest Disclosure: NONE
SESSION INFORMATION
Poster Session
Head and Neck Cancer: Oncogenesis, Invasion and Progression I
Thursday,
07/26/2018
, 11:30AM - 12:45PM