IADR Abstract Archives

Biomodification of Class-V Restorative Material by Incorporation of Bioactive Agents

Objectives: Glass ionomer cement (GIC) is the material of choice for restoring class-V cavities. However, there is a need for an improved restorative material to enable periodontal tissue attachment onto the surface of subgingival class-V restorations. Therefore, the aim of this study was biomodification of a GIC-based restorative system by incorporating bioactive materials to enhance soft tissue attachment
Methods: Six bioactive materials including Hydroxyapatite, Chitosan, Chondroitin Sulphate, Bio-glass, Gelatine and Processed Bovine Dentin were incorporated into a conventional GIC restorative material. Ten discs were prepared from each material to measure compressive strength, biaxial flexural strength and hardness. For setting and working time five discs were prepared. Biocompatibility was assessed using Presto-blue (PB) assay on normal oral fibroblasts (NOF), TR146 keratinocytes and 3D tissue engineered oral mucosa models (OMM) exposed to the test materials.
Results: Statistical analysis showed that the compressive strength of the biomodified restorative materials were comparable to the conventional GIC except for gelatine and chondroitin sulphate groups. For flexural strength, only gelatine group showed significantly lower values. For hardness and setting time, no statistically significant difference was observed between the groups except for bio-glass which showed significantly higher working time, compared to the conventional GIC. Biocompatibility testing using NOF monolayer cell culture systems and OMM showed processed bovine dentin and bio-glass groups had significantly higher cell viability in comparison with the conventional GIC.
Conclusions:
The addition of processed bovine dentin and bio-glass to the conventional GIC enhances the material’s bioactivity without compromising its mechanical properties and therefore may have a potential clinical application in subgingival class-V restorations to enhance periodontal soft tissue attachment.
IADR/PER General Session
2018 IADR/PER General Session (London, England)
London, England
2018
2438
Dental Materials 5: Biocompatibility, Bioengineering and Biologic Effects of Materials
  • Binaljadm, Tahani  ( University of Sheffield , Sheffield , United Kingdom )
  • Moorehead, Robert  ( University of Sheffield , Sheffield , United Kingdom )
  • Almela, Thafar  ( University of Sheffield , Sheffield , United Kingdom )
  • Franklin, Kirsty  ( University of Sheffield , Sheffield , United Kingdom )
  • Tayebi, Lobat  ( Marquette University , Milwaukee , Wisconsin , United States )
  • Moharamzadeh, Keyvan  ( University of Sheffield , Sheffield , United Kingdom )
  • NONE
    Poster Session
    Biocompatibility, Bioengineering and Biologic Effects of Materials VI
    Friday, 07/27/2018 , 03:45PM - 05:00PM