IADR Abstract Archives
TiF4 Varnish for Treatment of Caries in Children Permanent Dentition
Objectives: This 6-month randomized clinical trial (RTC) compared the effect of 4% TiF4 varnish with a commercial 5% NaF varnish in the treatment of noncavitated enamel carious lesions in permanent teeth of children living in a fluoridated area.
Methods: This randomized, controlled, parallel and single blind clinical trial involved 63 children, 6-7 years old, living in Bauru-SP/Brazil. Children were selected according to their caries activity (presence of at least 1 tooth with score Nyvad 1) and randomly divided into the following treatments: 4% TiF4 varnish (2.45% F-, pH 1, FGM); 5% NaF varnish (2.26% F-, pH 5, Duraphat®, Colgate) and negative control (placebo varnish, pH 5, FGM). The varnishes were applied on all permanent teeth, once a week for 4 consecutive weeks. Two calibrated examiners carried out the clinical examination (Nyvad index, kappa>0.8) at baseline, after the 1st and 6th month of the beginning of the study. Quantitative fluorescence changes were also measured using QLF device at the same periods. The degree of patient satisfaction with the treatment was also reported.
Results: Slight clinical and fluorescence changes were seen in the lesions during the period of the study. No significant differences between treatments with respect to caries lesions regression or progression (Nyvad-index) were detected after the 1st (Kruskal-Wallis/Wilcoxon, p>0.05) and the 6th month (Table 1). Also no differences between the treatments were detected with respect to the lesion area (WS) and the mean fluorescence loss (ΔF) (ANOVA/Kruskal-Wallis, p>0.05, Table 1). Regardless of the treatment, more than 75% of the participants reported to be satisfied with the treatments.
Conclusions: In conclusion, the fluoride treatments did not improve remineralization of noncavitated enamel carious lesions during 6 months of follow up. The participants will be still under follow up for a total period of 18 months, to check possible differences between the fluoride varnishes.
Methods: This randomized, controlled, parallel and single blind clinical trial involved 63 children, 6-7 years old, living in Bauru-SP/Brazil. Children were selected according to their caries activity (presence of at least 1 tooth with score Nyvad 1) and randomly divided into the following treatments: 4% TiF4 varnish (2.45% F-, pH 1, FGM); 5% NaF varnish (2.26% F-, pH 5, Duraphat®, Colgate) and negative control (placebo varnish, pH 5, FGM). The varnishes were applied on all permanent teeth, once a week for 4 consecutive weeks. Two calibrated examiners carried out the clinical examination (Nyvad index, kappa>0.8) at baseline, after the 1st and 6th month of the beginning of the study. Quantitative fluorescence changes were also measured using QLF device at the same periods. The degree of patient satisfaction with the treatment was also reported.
Results: Slight clinical and fluorescence changes were seen in the lesions during the period of the study. No significant differences between treatments with respect to caries lesions regression or progression (Nyvad-index) were detected after the 1st (Kruskal-Wallis/Wilcoxon, p>0.05) and the 6th month (Table 1). Also no differences between the treatments were detected with respect to the lesion area (WS) and the mean fluorescence loss (ΔF) (ANOVA/Kruskal-Wallis, p>0.05, Table 1). Regardless of the treatment, more than 75% of the participants reported to be satisfied with the treatments.
Conclusions: In conclusion, the fluoride treatments did not improve remineralization of noncavitated enamel carious lesions during 6 months of follow up. The participants will be still under follow up for a total period of 18 months, to check possible differences between the fluoride varnishes.