IADR Abstract Archives
Histomorphometric Analysis of Bone Repair Using Hydroxyapatite and Xenogeneic Bone
Objectives: This study evaluated by means of histology and histomorphometry two bone substitutes, a deproteinized bovine bone (DBB) and a derived ceramic biphasic calcium phosphate (BCP), associated with autogenous bone in the repair of critical defects in rat calvarium.
Methods: Fifty-four Wistar Rattus norvegicus albinos were divided into 3 groups: control group AB (autogenous bone), AB and DBB group (autogenous bone associated to deproteinized bovine bone) and BCP (autogenous bone associated to biphasic calcium phosphate). Experimental times were 4, 8 and 12 weeks.
Results: Both biomaterials analyzed showed osteoconductivity and new bone formation in the three experimental periods. Immature bone were deposited around BCP, whereas new bone formation was observed around and inner the particles of DBB. BCP showed higher quantity of immature bone when compared to DBB, especially in 4 and 8 weeks. There was no statistical significant difference in the percentage of immature bone between DBB and BCP in all experimental periods. DBB showed the lowest percentage of mature bone formation at 8 weeks.
Conclusions: BCP showed higher formation of immature bone and earlier reabsorption than DBB. BCP group showed better quality of immature bone, however there is no statistical significant difference when compared with DBB group.
Methods: Fifty-four Wistar Rattus norvegicus albinos were divided into 3 groups: control group AB (autogenous bone), AB and DBB group (autogenous bone associated to deproteinized bovine bone) and BCP (autogenous bone associated to biphasic calcium phosphate). Experimental times were 4, 8 and 12 weeks.
Results: Both biomaterials analyzed showed osteoconductivity and new bone formation in the three experimental periods. Immature bone were deposited around BCP, whereas new bone formation was observed around and inner the particles of DBB. BCP showed higher quantity of immature bone when compared to DBB, especially in 4 and 8 weeks. There was no statistical significant difference in the percentage of immature bone between DBB and BCP in all experimental periods. DBB showed the lowest percentage of mature bone formation at 8 weeks.
Conclusions: BCP showed higher formation of immature bone and earlier reabsorption than DBB. BCP group showed better quality of immature bone, however there is no statistical significant difference when compared with DBB group.