IADR Abstract Archives
Two-Week Efficacy of an Occluding Dentifrice on Dentinal Hypersensitivity
Objectives: To investigate the efficacy of an experimental anhydrous 0.454% w/w stannous fluoride dentifrice in relieving dentinal hypersensitivity (DH) after 7 and 14 days’ brushing compared with a 0.76% w/w sodium monofluorophosphate marketed control dentifrice.
Methods: This was a single-center, randomized, examiner-blind, two-treatment arm, stratified, controlled, parallel-design study in otherwise healthy subjects with DH (N=141). Two non-adjacent teeth with DH were selected and tactile threshold (Yeaple probe) and evaporative air sensitivity (Schiff sensitivity score) were assessed at baseline. Subjects brushed twice-daily for at least 1 minute with their assigned dentifrice; those using the Experimental dentifrice also included an initial focused brushing of test teeth. Schiff sensitivity and tactile threshold scores were re-assessed after 7 and 14 days.
Results: The Experimental dentifrice reduced DH, as assessed by both Schiff and tactile threshold measures, compared to baseline after 7 and 14 days’ use (all p<.0001). The Control dentifrice had no significant effect on DH at either time-point. The Experimental dentifrice demonstrated a reduction in DH compared to Control for both measures at both time-points (all p<.0001). Study products were generally well-tolerated.
Conclusions: The 0.454% stannous fluoride-containing Experimental dentifrice demonstrated statistically significantly greater changes in two indices of DH after both 7 and 14 days’ use than a marketed control dentifrice.
Methods: This was a single-center, randomized, examiner-blind, two-treatment arm, stratified, controlled, parallel-design study in otherwise healthy subjects with DH (N=141). Two non-adjacent teeth with DH were selected and tactile threshold (Yeaple probe) and evaporative air sensitivity (Schiff sensitivity score) were assessed at baseline. Subjects brushed twice-daily for at least 1 minute with their assigned dentifrice; those using the Experimental dentifrice also included an initial focused brushing of test teeth. Schiff sensitivity and tactile threshold scores were re-assessed after 7 and 14 days.
Results: The Experimental dentifrice reduced DH, as assessed by both Schiff and tactile threshold measures, compared to baseline after 7 and 14 days’ use (all p<.0001). The Control dentifrice had no significant effect on DH at either time-point. The Experimental dentifrice demonstrated a reduction in DH compared to Control for both measures at both time-points (all p<.0001). Study products were generally well-tolerated.
Conclusions: The 0.454% stannous fluoride-containing Experimental dentifrice demonstrated statistically significantly greater changes in two indices of DH after both 7 and 14 days’ use than a marketed control dentifrice.